2-alkenal reductase

Class of enzymes 2-alkenal reductase 1.3.1.74 9032-20-6 0032440 1zsv.jpg 270 Leukotriene B4 12-hydroxydehydrogenase (NADP-dependent) dimer, Human In enzymology, a 2-alkenal reductase (1.3.1.74) is an enzyme that catalyzes the chemical reaction n-alkanal + NAD(P)+ alk-2-enal + NAD(P)H + H+ The three substrates of this enzyme are n-alkanal, NAD+, and NADP+, whereas its four products are alk-2-enal, NADH, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase. Structural studies As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes 2DM6, 2J3J, and 2J3K. References 1 Mano J, Torii Y, ((Hayashi S-I)) etal 2002 The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes Plant Cell Physiol. 43 1445–55 12514241 10.1093/pcp/pcf187 12 free Dick RA, Kwak MK, Sutter TR, Kensler TW 2001 Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase J. Biol. Chem. 276 40803–10 11524419 10.1074/jbc.M105487200 44 free Biology no Category:EC 1.3.1 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Enzymes of known structure