411 REFERENCE · Wikipedia
2-Oxohistidine
Reference material by Wikipedia contributors. This retains its source identity and is not 411 news reporting.
2-oxohistidine.svg 200px 3-(2-Oxo-2H-imidazol-4-yl)alanine 181996-08-7 19981749 127761 C1=NC(=O)N=C1CC(C(=O)O)N 1S/C6H7N3O3/c7-4(5(10)11)1-3-2-8-6(12)9-3/h2,4H,1,7H2,(H,10,11) COPY MWUSZYAURGSGRY-UHFFFAOYSA-N
6 7 3 3 white solid
2-Oxohistidine is a derivative of histidine damaged by reactive oxygen species. It is a biological marker for assessing protein modifications from oxidative stress.8405458 2-Oxo-histidine as a novel biological marker for oxidatively modified proteins FEBS Lett 1993 332 3 208–210 Uchida K, Kawakishi S 10.1016/0014-5793(93)80632-5 free 1993FEBSL.332..208U In particular, it arises by iron-catalyzed reaction with hydrogen peroxide.10.1038/nature04537 The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation 2006 Lee Jin-Won Helmann John D. Nature 440 7082 363–367 16541078
References
Category:Alpha-amino acids
Category:Amino acid derivatives