2,4-diaminopentanoate dehydrogenase

Class of enzymes 2,4-diaminopentanoate dehydrogenase 1.4.1.12 39346-26-4 0047530 In enzymology, 2,4-diaminopentanoate dehydrogenase (1.4.1.12) is an enzyme that catalyzes the chemical reaction 55% Q27106323 2,4-diaminopentanoic acid + NAD+ reversible H2O H+ H2O H+ Q76100165 2-amino-4-oxopentanoic acid + NADH + NH3 The substrates of this enzyme are (2R,4S)-2,4-diaminopentanoic acid, water, and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are (2R)-2-amino-4-oxopentanoic acid, reduced NADH, ammonia, and a proton. Nicotinamide adenine dinucleotide phosphate can be used as an alternative cofactor.1.4.1.12Somack R, Costilow RN 1973 2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein J. Biol. Chem. 248 385–8 4684685 2 10.1016/S0021-9258(19)44384-6 free Stadtman TC 1973 Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase) Adv. Enzymol. Relat. Areas Mol. Biol. 38 441–445 Tsuda Y, Friedmann HC 1970 Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide J. Biol. Chem. 245 5914–26 4394942 22 10.1016/S0021-9258(18)62643-2 free This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating). This enzyme is also called 2,4-diaminopentanoic acid C4 dehydrogenase. This enzyme participates in 3 metabolic pathways: lysine degradation, arginine and proline metabolism, and d-arginine and d-ornithine metabolism. References Biology no Category:EC 1.4.1 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Enzymes of unknown structure