2-methyleneglutarate mutase

Class of enzymes 2-methyleneglutarate mutase 5.4.99.4 9059-10-3 0047548 In enzymology, a 2-methyleneglutarate mutase (5.4.99.4) is an enzyme that catalyzes the chemical reaction 2-methyleneglutarate 2-methylene-3-methylsuccinate Hence, this enzyme has one substrate, 2-methyleneglutarate, and one product, 2-methylene-3-methylsuccinate. This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methyleneglutarate carboxy-methylenemethylmutase. This enzyme is also called alpha-methyleneglutarate mutase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, cobamide. References 1 Kung HF, Cederbaum S, Tsai L, Stadtman TC 1970 Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid Proc. Natl. Acad. Sci. U.S.A. 65 978–84 5266166 10.1073/pnas.65.4.978 4 283012 1970PNAS...65..978K free Kung HF, Stadtman TC 1971 Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase J. Biol. Chem. 246 3378–88 5574401 10 10.1016/S0021-9258(18)62235-5 free Biology no Category:EC 5.4.99 Category:Cobamide enzymes Category:Enzymes of unknown structure