1,3-Beta-glucan synthase

Class of enzymes GS-II other GS2 (disambiguation)GS2 1,3-Beta-glucan synthase 2.4.1.34 9037-30-3 GS-II, KFLGG, ENZYME: 2.4.1.34 paramylon synthetase, callose synthase Glucan_synthase Glycosyl transferase, family 48 (GT48) PF02364 CL0111 IPR003440 GT48 1,3-Beta-glucan synthase is a glucosyltransferase enzyme involved in the generation of beta-glucan in fungi. It serves as a pharmacological target for antifungal drugs such as caspofungin, anidulafungin, and micafungin, deemed 1,3-Beta-glucan synthase inhibitors. Under the CAZy classification system, fungi and plant members fall in the glycosyltransferase 48 family (GT48).Campbell JA, Davies GJ, Bulone V, Henrissat B A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities Biochem. J. 326 3 929–39 September 1997 9334165 1218753 10.1042/bj3260929u Some members of the glycosyltransferase 2 family (PF13632), such as the curdlan synthase CrdS (Q9X2V0), also has a similar activity. Karnezis T, Epa VC, Stone BA, Stanisich VA Topological characterization of an inner membrane (1→3)-beta-D-glucan (curdlan) synthase from Agrobacterium sp. strain ATCC31749 Glycobiology 13 10 693–706 2003 12851288 10.1093/glycob/cwg093 free The biosynthesis of disaccharides, oligosaccharides, and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The family consists of various 1,3-beta-glucan synthase components including Gls1, Gls2, and Gls3 from yeast. 1,3-Beta-glucan synthase (2.4.1.34.) also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal cell wall.Mio T, Adachi-Shimizu M, Tachibana Y, Tabuchi H, Inoue SB, Yabe T, Yamada-Okabe T, Arisawa M, Watanabe T, Yamada-Okabe H Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1/FKS1 and its involvement in beta-1,3-glucan synthesis J. Bacteriol. 179 13 4096–105 July 1997 9209021 179227 10.1128/jb.179.13.4096-4105.1997 The reaction catalysed is: UDP-glucose + {(1,3)-beta-D-glucosyl}(N) = UDP + {(1,3)-beta-D-glucosyl}(N+1). See also Echinocandin glucan External links 2.4.1.34 glucan+synthase CAZy References Biology no IPR003440 Category:EC 2.4.1 Category:Proteins