16α-Hydroxyandrostenedione

16α-Hydroxyandrostenedione.svg skin-invert-image 250px 16α-Hydroxyandrost-4-ene-3,17-dione (2R,3aS,3bR,9aR,9bS,11aS)-2-Hydroxy-9a,11a-dimethyl-2,3,3a,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[a]phenanthrene-1,7(3bH)-dione 16α-OH-A4 63-02-5 27582 1908014 389474 440574 C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3C[C@H](C4=O)O)C 1S/C19H26O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h9,13-16,21H,3-8,10H2,1-2H3/t13-,14+,15+,16-,18+,19+/m1/s1 SSBCZTXGVMMZOT-NBBHSKLNSA-N JN8H7214IR 19 26 3 302.414 g/mol 16α-Hydroxyandrostenedione (16α-OH-A4), also known as 16α-hydroxyandrost-4-ene-3,17-dione, is an endogenous and naturally occurring steroid and metabolic intermediate in the biosynthesis of estriol during pregnancy.Rodney Rhoades David R. Bell Medical Physiology: Principles for Clinical Medicine https://books.google.com/books?id=tBeAeYS-vRUC&pg=PA713 2009 Lippincott Williams & Wilkins 978-0-7817-6852-8 713–714Charles Graham Reproductive Biology of the Great Apes: Comparative and Biomedical Perspectives https://books.google.com/books?id=iUA0CdGhYksC&pg=PA56 2 December 2012 Elsevier 978-0-323-14971-6 56–Vitamins and Hormones https://books.google.com/books?id=DUst5mwBfN0C&pg=PA282 7 September 2005 Academic Press 978-0-08-045978-3 282– It is produced from dehydroepiandrosterone (DHEA), which is converted into 16α-hydroxy-DHEA sulfate, then desulfated and aromatized into 16α-hydroxyestrone, and finally converted into estriol by 17β-hydroxysteroid dehydrogenase. See also 15α-Hydroxydehydroepiandrosterone Androstenedione 11β-Hydroxyandrostenedione References 2 Category:Androstanes Category:Steroid hormones