2-Deoxystreptamine N-acetyl-D-glucosaminyltransferase

Class of enzymes 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase 2.4.1.283 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase (2.4.1.283, btrM (gene), neoD (gene), kanF (gene)) is an enzyme with systematic name UDP-N-acetyl-alpha-D-glucosamine:2-deoxystreptamine N-acetyl-D-glucosaminyltransferase.2.4.1.283 It catalyses the following chemical reaction 65% UDP-N-acetyl-D-glucosamine + Q27103617 2-deoxystreptamine UDP Q27133579 2'-N-acetylparomamine 1.5 thumb|Kanamycin A The enzyme transfers an N-acetylglucosamine sugar unit to one of the hydroxy groups of the aminoglycoside, 2-deoxystreptamine, giving 2'-N-acetylparomamine and uridine diphosphate (UDP). This is an early step in the biosynthesis of clinically important aminoglycoside antibiotics including neomycin and kanamycin. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis ChemBioChem 9 6 865–9 April 2008 18311744 10.1002/cbic.200700717 Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation Nature Chemical Biology 7 11 843–52 October 2011 21983602 10.1038/nchembio.671 References External links 2-deoxystreptamine+N-acetyl-D-glucosaminyltransferase Biology no Category:EC 2.4.1