(heparan sulfate)-glucosamine 3-sulfotransferase 3

Class of enzymes (heparan sulfate)-glucosamine 3-sulfotransferase 3 2.8.2.30 In enzymology, a [heparan sulfate]-glucosamine 3-sulfotransferase 3 (2.8.2.30) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and heparan sulfate-glucosamine, whereas its two products are adenosine 3',5'-bisphosphate and heparan sulfate-glucosamine 3-sulfate. This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase. This enzyme participates in heparan sulfate biosynthesis and glycan structures - biosynthesis 1. References 1 RD 1999 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues J. Biol. Chem. 274 38155–62 10608887 10.1074/jbc.274.53.38155 Shriver Z Blaiklock P Yoshida K Sasisekharan R Rosenberg RD 53 free Eisenberg RJ, Rosenberg RD, Spear PG 1999 A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry Cell 99 13–22 10520990 10.1016/S0092-8674(00)80058-6 1 free Jenkins NA, Rosenberg RD 1999 Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci J. Biol. Chem. 274 5170–84 9988767 10.1074/jbc.274.8.5170 8 free Rosenberg RD 1999 Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities J. Biol. Chem. 274 5185–92 9988768 10.1074/jbc.274.8.5185 Shworak NW Sinaÿ P Schwartz JJ Zhang L Fritze LM Rosenberg RD 8 free Biology no Category:EC 2.8.2 Category:Enzymes of unknown structure