2-Fluoromethcathinone

November 2024 Designer stimulant vanc 6 2-Fluoromethcathinone.svg skin-invert-image 185px Stimulant; Norepinephrine–dopamine releasing agent 1186137-35-8 71316821 37701826 7NLX9J64KY 2-FMC; 2-Fluoromethylcathinone; 2-Fluoro-N-methylcathinone; 2-Flephedrone 1-(2-fluorophenyl)-2-(methylamino)propan-1-one 10 12 1 1 1 CC(C(=O)C1=CC=CC=C1F)NC 1S/C10H12FNO/c1-7(12-2)10(13)8-5-3-4-6-9(8)11/h3-7,12H,1-2H3 DCMOUMKIDLRIBO-UHFFFAOYSA-N 2-Fluoromethcathinone (2-FMC), also known as 2-flephedrone, is a psychostimulant and designer drug of the cathinone family. Kelly JP Cathinone derivatives: a review of their chemistry, pharmacology and toxicology Drug Test Anal 3 7–8 439–453 2011 21755607 10.1002/dta.313 Glennon RA Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse Bath salts, mephedrone, and methylenedioxypyrovalerone as emerging illicit drugs that will need targeted therapeutic intervention Adv Pharmacol 69 581–620 2014 24484988 4471862 10.1016/B978-0-12-420118-7.00015-9 978-0-12-420118-7 Kelleher C, Christie R, Lalor K, Fox J, Bowden M, O'Donnell C An Overview of New Psychoactive Substances and the Outlets Supplying them Reports 30 June 2011 10.21427/43F1-XR91 https://arrow.tudublin.ie/cserrep/23/ 24 November 2024 Blough BE, Decker AM, Landavazo A, Namjoshi OA, Partilla JS, Baumann MH, Rothman RB The dopamine, serotonin and norepinephrine releasing activities of a series of methcathinone analogs in male rat brain synaptosomes Psychopharmacology (Berl) 236 3 915–924 March 2019 30341459 6475490 10.1007/s00213-018-5063-9 It acts as a dopamine and norepinephrine releasing agent (NDRA). Pharmacology The drug has an EC50 half-maximal effective concentration for dopamine release of 48.7nM and induces 85% release of norepinephrine at a concentration of 10μM. For comparison, the EC50 half-maximal effective concentration values of methcathinone are 49.9nM for dopamine release and 22.4nM for norepinephrine release and it induces 100% release of norepinephrine at a concentration of 10μM. Blough B Dopamine-releasing agents Trudell ML, Izenwasser S Dopamine Transporters: Chemistry, Biology and Pharmacology 305–320 July 2008 978-0-470-11790-3 181862653 OL18589888W Wiley Hoboken [NJ] https://books.google.com/books?id=QCagLAAACAAJ https://bitnest.netfirms.com/external/Books/Dopamine-releasing-agents_c11.pdf Hence, compared to methcathinone, 2-FMC appears to be relatively more selective or efficacious for induction of dopamine release over norepinephrine release. It is notable in this regard that selective dopamine releasing agents are largely unknown. Negus SS, Mello NK, Blough BE, Baumann MH, Rothman RB Monoamine releasers with varying selectivity for dopamine/norepinephrine versus serotonin release as candidate "agonist" medications for cocaine dependence: studies in assays of cocaine discrimination and cocaine self-administration in rhesus monkeys J Pharmacol Exp Ther 320 2 627–636 February 2007 17071819 10.1124/jpet.106.107383 See also 3-Methoxymethcathinone 3-Fluoromethcathinone 4-Fluoromethcathinone (flephedrone) 2-Fluoromethamphetamine References External links 2-FMC (2-Fluoromethcathinone) - Isomer Design Category:2-Fluorophenyl compounds Category:Cathinones Category:Designer drugs Category:Methamphetamines Category:Norepinephrine-dopamine releasing agents Category:Stimulants