2-dehydro-3-deoxyglucarate aldolase

Class of enzymes 2-dehydro-3-deoxyglucarate aldolase 4.1.2.20 37290-56-5 0008672 4tv6.jpg 270 2-dehydro-3-deoxyglucarate aldolase hexamer, Staphylococcus aureus The enzyme 2-dehydro-3-deoxyglucarate aldolase (4.1.2.20) catalyzes the chemical reaction 2-dehydro-3-deoxy-D-glucarate pyruvate + tartronate semialdehyde This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxyglucarate aldolase, alpha-keto-beta-deoxy-D-glucarate aldolase, and 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase. This enzyme participates in ascorbate and aldarate metabolism. Structural studies As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1DXE, 1DXF, 1W37, 1W3I, 1W3N, and 1W3T. References 1 Fish DC, Blumenthal HJ 1966 2-Keto-3-deoxy-D-glucarate aldolase 9 529–534 10.1016/0076-6879(66)09105-5 Carbohydrate Metabolism Methods in Enzymology 978-0-12-181809-8 Biology no Category:EC 4.1.2 Category:Enzymes of known structure