2-oxoglutarate synthase

Class of enzymes 2-oxoglutarate synthase 1.2.7.3 37251-05-1 0047553 In enzymology, 2-oxoglutarate synthase (1.2.7.3) is an enzyme that catalyzes the chemical reaction 60% upright=1|class=skin-invert-image succinyl-CoA + 2 reducedferredoxin reversible CO2 + 2 H+ CO2 + 2 H+ α-Ketoglutaric acid 2-oxoglutaric acid 1.2 + coenzyme A+ 2 oxidisedferredoxin The substrates of this enzyme are succinyl-CoA, reduced ferredoxin, carbon dioxide and two protons. Its products are 2-oxoglutaric acid, coenzyme A, and oxidized ferredoxin. This reaction is part of the reverse Krebs cycle, as a means of carbon fixation.1.2.7.3Buchanan BB, Evans MC 1965 The synthesis of alpha-ketoglutarate from succinate and carbon dioxide by a subcellular preparation of a photosynthetic bacterium Proc. Natl. Acad. Sci. U.S.A. 54 1212–8 4286833 10.1073/pnas.54.4.1212 4 219840 1965PNAS...54.1212B free Gehring U, Arnon DI 1972 Purification and properties of -ketoglutarate synthase from a photosynthetic bacterium J. Biol. Chem. 247 6963–9 4628267 21 10.1016/S0021-9258(19)44680-2 free This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating). Other names in common use include 2-ketoglutarate ferredoxin oxidoreductase, 2-oxoglutarate:ferredoxin oxidoreductase, KGOR, 2-oxoglutarate ferredoxin oxidoreductase, and 2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating). In the direction from 2-oxoglutaric acid to succinyl-CoA the enzyme is part of the citric acid cycle.Dorner E, Boll M 2002 Properties of 2-Oxoglutarate:Ferredoxin Oxidoreductase from Thauera aromatica and Its Role in Enzymatic Reduction of the Aromatic Ring J. Bacteriol. 184 3975–83 12081970 10.1128/JB.184.14.3975-3983.2002 14 135165 Mai X, Adams MW 1996 Characterization of a fourth type of 2-keto acid-oxidizing enzyme from a hyperthermophilic archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis J. Bacteriol. 178 5890–6 8830683 20 10.1128/jb.178.20.5890-5896.1996 178443 Schut GJ, Menon AL, Adams MW 2-keto acid oxidoreductases from Pyrococcus furiosus and Thennococcus litoralis 2001 Hyperthermophilic enzymes Part B 331 144–58 11265457 10.1016/S0076-6879(01)31053-4 Methods in Enzymology 978-0-12-182232-3 References Biology no Category:EC 1.2.7 Category:Enzymes of unknown structure