2-Propanoyl-3-(4-isopropylphenyl)-tropane

Chemical compound 449586774 2-Propanoyl-3-(4-isopropylphenyl)-tropane WF-31.svg skin-invert-image 220 correct CAS 162809-72-5 278122 23121202 44458747 correct drugbank CCC(=O)C1C2N(C)C(CC2)CC1c3ccc(C(C)C)cc3 1S/C20H29NO/c1-5-19(22)20-17(12-16-10-11-18(20)21(16)4)15-8-6-14(7-9-15)13(2)3/h6-9,13,16-18,20H,5,10-12H2,1-4H3 BVSOMKYAWFJCTH-UHFFFAOYSA-N 20 29 1 1 2-Propanoyl-3-(4-isopropylphenyl)-tropane (WF-31, PIT) is a cocaine analogue which acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). Research shows WF-31 to be approximately ten times more potent than cocaine at binding to the serotonin transporter and at inhibiting its reuptake. Porrino LJ, Miller M, Hedgecock AA, Thornley C, Matasi JJ, Davies HM Local cerebral metabolic effects of the novel cocaine analog, WF-31: comparisons to fluoxetine Synapse (New York, N.Y.) 27 1 26–35 September 1997 9268062 10.1002/(SICI)1098-2396(199709)27:1<26::AID-SYN3>3.0.CO;2-F 25320475 See also List of cocaine analogues References Category:Tropanes Category:Serotonin–norepinephrine–dopamine reuptake inhibitors Category:Stimulants Category:Ketones Category:Isopropyl compounds