2,5-dihydroxypyridine 5,6-dioxygenase

Class of enzymes 2,5-dihydroxypyridine 5,6-dioxygenase 1.13.11.9 9029-57-6 0047075 2,5-dihydroxypyridine 5,6-dioxygenase (1.13.11.9) is an enzyme that catalyzes the chemical reaction 45% Q27101869 2,5-dihydroxypyridine O2 Q27126970 N-formylmaleamic acid The two substrates of this enzyme are 2,5-dihydroxypyridine and oxygen. Its product is N-formylmaleamic acid.1.13.11.9Behrman E.J. Stanier R.Y. The Bacterial Oxidation of Nicotinic Acid Journal of Biological Chemistry 1957 228 2 923–945 10.1016/S0021-9258(18)70671-6 free 13475371 Gauthier Joseph J. Rittenberg Sydney C. The Metabolism of Nicotinic Acid Journal of Biological Chemistry 1971 246 11 3737–3742 10.1016/S0021-9258(18)62189-1 free Gauthier Joseph J. Rittenberg Sydney C. The Metabolism of Nicotinic Acid Journal of Biological Chemistry 1971 246 11 3743–3748 10.1016/S0021-9258(18)62190-8 free Behrman E. J. N -Formylmaleamic acid: An intermediate in nicotinic acid metabolism Proceedings of the National Academy of Sciences 2008 105 47 E88; author reply E89 10.1073/pnas.0808695105 free 19020104 2587544 This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. It employs one cofactor, iron. This enzyme participates in nicotinate and nicotinamide metabolism.Henke Matthew T. Snider Mark J. Mechanistic studies of 2,5-dihydroxypyridine 5,6-dioxygenase (NicX) from Bordetella bronchiseptica The FASEB Journal 1 April 2011 25 1 Supplement 714.2 https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.25.1_supplement.714.2 0892-6638 10.1096/fasebj.25.1_supplement.714.2 28 February 2026 free Nomenclature The systematic name of this enzyme class is 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase. Other names in common use include 2,5-dihydroxypyridine oxygenase, and pyridine-2,5-diol dioxygenase. References Biology no Category:EC 1.13.11 Category:Iron enzymes Category:Enzymes of unknown structure