2,8-Dihydroxyadenine

vanc changed 477193857 Dihydroxyadenine.png 200px 6-Amino-1H-purine-2,8(7H,9H)-dione correct chemspider 83302 183641 1/C5H5N5O2/c6-2-1-3(9-4(11)7-1)10-5(12)8-2/h(H5,6,7,8,9,10,11,12) XFBOJHLYDJZYSP-UHFFFAOYAF correct chemspider 1S/C5H5N5O2/c6-2-1-3(9-4(11)7-1)10-5(12)8-2/h(H5,6,7,8,9,10,11,12) correct chemspider XFBOJHLYDJZYSP-UHFFFAOYSA-N changed ?? 30377-37-8 correct FDA MYE4YC3VKU 92268 O=C2N/C/1=N/C(=O)N\C(=C\1N2)N 2,8-dihydroxyadenine C5H5N5O2 167.126 2,8-Dihydroxyadenine is a derivative of adenine which accumulates in 2,8 dihydroxy-adenine urolithiasis. The poorly soluble purine 2,8-dihydroxyadenine is excreted in the urine because of a deficiency in the adenine salvage enzyme adenine phosphoribosyltransferase. The defect is inherited as an autosomal recessive trait; the homozygous state is associated with high urinary levels of 2,8-dihydroxyadenine and with crystalluria, calculus formation, and potential nephrotoxicity. The condition primarily presents as renal obstructive disease, but some patients have presented with advanced kidney failure. Allopurinol therapy appears to be effective. 2, 8-dihydroxyadenine formation can be easily controlled with allopurinol, which is administered in a dose of 300 mg/day in adults (10 mg/kg/day in children) in the absence of kidney failure.Gault M. Henry Simmonds H. Anne Snedden Walter Dow Donald Churchill David N. Penney Harold 1981-12-24 Urolithiasis Due to 2,8-Dihydroxyadenine in an Adult New England Journal of Medicine en 305 26 1570–1572 10.1056/NEJM198112243052608 7311997 0028-4793 References Electrochemical behaviour of 2,8-dihydroxyadenine at a glassy carbon electrode Bioelectrochemistry 70 1 141–6 2007 16713382 Diculescu VC Piedade JA Oliveira-Brett AM 10.1016/j.bioelechem.2006.03.015 10316/5065 free Taniguchi A, Tsuchida S, Kuno S, Mita M, Machida T, Ioritani N, Terai C, Yamanaka H, Kamatani N Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine urolithiasis Nucleosides Nucleotides Nucleic Acids 23 8–9 1141–5 2004 15571218 10.1081/NCN-200027393 38050144 Wilkinson H, Samuell C, Stower M 2,8-Dihydroxyadenine renal stones in a 41-year-old man Ann Clin Biochem 41 Pt 2 160–1 2004 15025810 10.1258/000456304322880087 free Category:Purines