2-Methoxyestrone

2-Methoxyestrone.svg skin-invert-image 200px 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one (3aS,3bR,9bS,11aS)-7-Hydroxy-8-methoxy-11a-methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthren-1-one 2-ME1; 2-MeOE1; 2-MeO-E1; 2-Hydroxyestrone 2-methyl ether; 2-Methoxyestra-1,3,5(10)-trien-3-ol-17-one 362-08-3 1189 425194 389515 C05299 440624 1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1 WHEUWNKSCXYKBU-QPWUGHHJSA-N C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=CC(=C(C=C34)OC)O SJ5857RRL3 19 24 3 2-Methoxyestrone (2-ME1) is an endogenous, naturally occurring methoxylated catechol estrogen and metabolite of estrone that is formed by catechol O-methyltransferase via the intermediate 2-hydroxyestrone.http://www.hmdb.ca/metabolites/hmdb00010 Human Metabolome Database: Showing metabocard for 2-Methoxyestrone (HMDB0000010) Anna R. Hemnes vanc Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide https://books.google.com/books?id=4So3CwAAQBAJ&pg=PA32 16 December 2015 Humana Press 978-3-319-23998-9 32– Christian Lauritzen John W. W. Studd vanc Current Management of the Menopause https://books.google.com/books?id=WD7S7677xUUC&pg=PA378 22 June 2005 CRC Press 978-0-203-48612-2 378–379 Unlike estrone but similarly to 2-hydroxyestrone and 2-methoxyestradiol, 2-methoxyestrone has very low affinity for the estrogen receptor and lacks significant estrogenic activity. Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women Journal of the Society for Gynecologic Investigation 7 3 175–83 2000 10865186 10.1016/s1071-5576(00)00049-6 See also 2-Methoxyestradiol 2-Methoxyestriol 4-Methoxyestradiol 4-Methoxyestrone References External links Metabocard for 2-Methoxyestrone - Human Metabolome Database Category:Estranes Category:Ethers Category:Human metabolites Category:Ketones Category:Hydroxyarenes