(acetyl-CoA carboxylase) kinase

Class of enzymes [acetyl-CoA carboxylase] kinase 2.7.11.27 77000-06-7 0050405 In enzymology, a [acetyl-CoA carboxylase] kinase (2.7.11.27) is an enzyme that catalyzes the chemical reaction ATP + [acetyl-CoA carboxylase] ADP + [acetyl-CoA carboxylase] phosphate Thus, the two substrates of this enzyme are ATP and acetyl-CoA carboxylase, whereas its two products are ADP and acetyl-CoA carboxylase phosphate. This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[acetyl-CoA carboxylase] phosphotransferase. Other names in common use include acetyl coenzyme A carboxylase kinase (phosphorylating), acetyl-CoA carboxylase bound kinase, acetyl-CoA carboxylase kinase, acetyl-CoA carboxylase kinase (cAMP-independent), acetyl-CoA carboxylase kinase 2, acetyl-CoA carboxylase kinase-2, acetyl-CoA carboxylase kinase-3 (AMP-activated), acetyl-coenzyme A carboxylase kinase, ACK2, ACK3, AMPK, I-peptide kinase, and STK5. References Jamil H, Madsen NB 1987 Phosphorylation state of acetyl-coenzyme A carboxylase. I. Linear inverse relationship to activity ratios at different citrate concentrations J. Biol. Chem. 262 630–7 2879833 2 10.1016/S0021-9258(19)75830-X free Lent B, Kim KH 1982 Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase J. Biol. Chem. 257 1897–901 6120170 4 10.1016/S0021-9258(19)68122-6 free Munday MR, Hardie DG 1984 Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity Eur. J. Biochem. 141 617–27 6146523 10.1111/j.1432-1033.1984.tb08237.x 3 free Mohamed AH, Huang WY, Huang W, Venkatachalam KV, Wakil SJ 1994 Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver J. Biol. Chem. 269 6859–65 7907095 9 10.1016/S0021-9258(17)37454-9 free Heesom KJ, Moule SK, Denton RM 1998 Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase FEBS Lett. 422 43–6 9475166 10.1016/S0014-5793(97)01597-4 1 1998FEBSL.422...43H Biology no Category:EC 2.7.11 Category:Enzymes of unknown structure