1V-LSD

Chemical compound vanc 6 January 2026 1V-LSD structure.svg skin-invert-image 225px 1V-LSD 3D.png bg-transparent 250px Oral Serotonergic psychedelic; Hallucinogen S8 Unscheduled NpSG PSA Unscheduled (when wasn't sold for human consumption) Unscheduled 6–8 hours (reportedly) 3028950-70-8 162368540 changed FDA V9TJ3HT283 1-Valeryl-LSD; 1-Valeroyl-LSD; 1-Pentanoyl-LSD; Valerie; 1-Valeryl-N,N-diethyllysergamide (6aR,9R)-N,N-Diethyl-7-methyl-4-pentanoyl-4,,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide 25 33 3 2 CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)CCCC)c4cccc2c34)N(C)C5 1S/C25H33N3O2/c1-5-8-12-23(29)28-16-17-14-22-20(19-10-9-11-21(28)24(17)19)13-18(15-26(22)4)25(30)27(6-2)7-3/h9-11,13,16,18,22H,5-8,12,14-15H2,1-4H3/t18-,22-/m1/s1 GIIBVGJWUZNECE-XMSQKQJNSA-N 1V-LSD, also known as 1-valeryl-LSD or by the nickname Valerie, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). 1V-LSD ru АИПСИН https://aipsin.com/newsubstance/719/ 1 January 2026 It is an analogue of LSD and is thought to act as a prodrug of LSD. Brandt SD, Kavanagh PV, Westphal F, Pulver B, Morton K, Stratford A, Dowling G, Halberstadt AL November 2021 Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1-valeroyl-d-lysergic acid diethylamide (1V-LSD) Drug Testing and Analysis 14 4 733–740 10.1002/dta.3205 9191648 34837347 The drug has been encountered as a novel designer recreational drug. Use and effects LSD#Uses LSD#Effects 1V-LSD has been sold in the form of blotter containing 150μg per tab. Its effects are said to be comparable to 100 to 120μg 1P-LSD or 1cP-LSD, but with a longer duration. On the other hand, other sources report that 1V-LSD has a shorter duration than LSD of 6 to 8hours.Niesporek Tom Der Hype um legales LSD in Deutschland: Wie das Verbot umgangen wird The hype surrounding legal LSD in Germany: How the ban is circumvented 2:10–8:12, 20:05–20:41 German VICE auf Deutsch YouTube 17 August 2022 https://www.youtube.com/watch?v=iVNCt2zyIaQ&t=130 29 September 2025 Niesporek T 17 August 2022 Wir haben den Erfinder von legalem LSD getroffen VICE https://www.vice.com/de/article/video-wir-haben-den-erfinder-von-legalem-lsd-getroffen-1v-lsd/ 29 September 2025 29 September 2025 https://web.archive.org/web/20250929014854/https://www.vice.com/de/article/video-wir-haben-den-erfinder-von-legalem-lsd-getroffen-1v-lsd/ We met the inventor of legal LSD Interactions Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes Pharmacology Pharmacodynamics As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act directly as a weak partial agonist at the serotonin 5-HT2A receptor. A head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs. Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD August 2020 Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD) Neuropharmacology 172 107856 10.1016/j.neuropharm.2019.107856 9191647 31756337 Chemistry Synthesis 1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety. Umehara A, Ueda H, Tokuyama H November 2016 Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O The Journal of Organic Chemistry 81 22 11444–11453 10.1021/acs.joc.6b02097 27767302 Detection Ehrlich's reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules. De Faubert Maunder MJ August 1974 A field test for hallucinogens: further improvements The Journal of Pharmacy and Pharmacology 26 8 637–638 10.1111/j.2042-7158.1974.tb10677.x 4155730 97915487 However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh. 16 July 2021 REACTIONS 1V-LSD PRO Test https://www.protestkit.eu/1v-lsd-reagent-testing-results/ 16 July 2021 1V-LSD reaction with the ehrlich reagent PRO Test https://www.protestkit.eu/1v-lsd-reagent-testing-results/ Analogues Related compounds include 1B-LSD, 1cP-LSD, 1D-LSD, 1P-LSD, and AL-LAD, among others. History 1V-LSD was first described in the scientific literature by 2022. Tanaka R, Kawamura M, Mizutani S, Kikura-Hanajiri R 2022 Analyses of LSD analogs in illegal products: The identification of 1cP-AL-LAD, 1cP-MIPLA and 1V-LSD Toxicologie Analytique et Clinique 34 3 S171 10.1016/j.toxac.2022.06.295 Society and culture Legal status thumb|left|150px|1v-LSD strip blotters. Canada 1V-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025. 5 December 2025 Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 20 January 2026 Germany An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect. Gesetzespanne: Gefährliche LSD-Derivate plötzlich legal https://www.lto.de/recht/hintergruende/h/lsd-derivate-drogen-legalisierung-strafbar-gesetztespanne-bmg-lauterbach-npsg-btmg/ The law was amended in March 2023, now banning 1V-LSD. Poland 1V-LSD has been a controlled substance in Poland since 2024.https://www.dziennikustaw.gov.pl/du/2024/1139 Obwieszczenie Ministra Zdrowia z dnia 17 czerwca 2024 r. w sprawie ogłoszenia jednolitego tekstu rozporządzenia Ministra Zdrowia w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych Notice of the Minister of Health of 17 June 2024 on the publication of the consolidated text of the regulation of the Minister of Health on the list of psychotropic substances, narcotics and new psychoactive substances Internetowy System Aktów Prawnych 17 June 2024 pl Dz.U. 2024 poz. 1139 15 September 2026 South Korea 1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.Kim Chan-hyuk, Regulator names 1V-LSD as narcotic drug temporarily. Korea Biomedical Review, 5 July 2022 Sweden Since 2 March 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled. United States 1V-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.21 U.S. Code § 813 - Treatment of controlled substance analogues https://www.law.cornell.edu/uscode/text/21/813 See also Substituted lysergamide Lizard Labs References External links 1V-LSD - Isomer Design 1V-LSD - PsychonautWiki The Small & Handy 1V-LSD Thread - Bluelight Meet Valerie: LSD's Stealthy Sidekick (1V-LSD) - Tripsitter 1V-LSD - Lysergamide Psychedelics - TripSitter 1V-LSD: The New Wave of Acid - Sociedelic From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides - Sociedelic Category:5-HT2A agonists Category:Designer prodrugs Category:Diethylamides Category:Lizard Labs Category:Methyl compounds Category:Psychedelic lysergamides Category:Serotonin receptor agonists Category:Valerate esters