2-Amino-4-hydroxy-6-pyrophosphoryl-methylpteridine

Pteridine diphosphate.svg correct ?? 244 Skeletal formula of 2-amino-4-hydroxy-6-pyrophosphoryl-methylpteridine (2-Amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl trihydrogen diphosphate Pteridine diphosphate 3545-84-4 correct CAS correct FDA CFG9B839S3 666 646 correct chemspider C04807 correct kegg 2-Amino-4-hydroxy-6-pyrophosphoryl-methylpteridine correct EBI 15998 1229984 correct EBI 8397629 B01816 C1C(=NC2=C(N1)NC(=NC2=O)N)COP(=O)(O)OP(=O)(O)O 1S/C7H11N5O8P2/c8-7-11-5-4(6(13)12-7)10-3(1-9-5)2-19-22(17,18)20-21(14,15)16/h1-2H2,(H,17,18)(H2,14,15,16)(H4,8,9,11,12,13) correct chemspider FCQGJGLSOWZZON-UHFFFAOYSA-N correct chemspider 7 11 5 8 2 -2.915 1.252 12.745 2-Amino-4-hydroxy-6-pyrophosphoryl-methylpteridine (7,8-Dihydropterin pyrophosphate, dihydropterin-CH2OH-diphosphate) is a pteridine; a precursor to dihydrofolic acid.10.1016/S0083-6729(08)00415-9 18804704 2008 Derrick J. P The structure and mechanism of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase Chapter 15 the Structure and Mechanism of 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase 79 411–33 Vitamins & Hormones 9780123742322 Biosynthesis The enzyme 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase converts 6-hydroxymethyl-7,8-dihydropterin to 2-amino-4-hydroxy-6-pyrophosphoryl-methylpteridine by transferring a pyrophosphate group from the cofactor, adenosine triphosphate (ATP).Richey DP, Brown GM 1969 The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid J. Biol. Chem. 244 1582–92 4304228 6 10.1016/S0021-9258(18)91799-0 free Shiota T, Baugh CM, Jackson R, Dillard R 1969 The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate Biochemistry 8 5022–8 4312465 10.1021/bi00840a052 12 Richey DP, Brown GM Hydroxymethyldihydropteridine pyrophosphokinase and dihydropteroate synthetase from Escherichia coli 1971 Vitamins and Coenzymes Methods Enzymol. 18B 765–771 10.1016/s0076-6879(71)18150-5 978-0-12-181880-7 60% Q106570944 6-Hydroxymethyl-7,8-dihydropterin reversible ATP AMP AMP ATP 2-Amino-4-hydroxy-6-pyrophosphoryl-methylpteridine 1.2 In organisms including Escherichia coli and Pneumocystis carinii this is a step in the biosynthesis of dihydrofolic acid.Talarico TL, Ray PH, Dev IK, Merrill BM, Dallas WS Cloning, sequence analysis, and overexpression of Escherichia coli folK, the gene coding for 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase J. Bacteriol. 174 18 5971–7 September 1992 1325970 207135 10.1128/jb.174.18.5971-5977.1992Volpe F, Dyer M, Scaife JG, Darby G, Stammers DK, Delves CJ The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase Gene 112 2 213–8 March 1992 1313386 10.1016/0378-1119(92)90378-3 References Category:Pteridines