1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

Class of enzymes 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase 1.3.1.25 60496-16-4 0047116 In enzymology, 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (1.3.1.25) is an enzyme that catalyzes the chemical reaction 50% Q27117304 1,6-dihydroxycyclohexa-2,4-dienecarboxylate + NAD+ reversible CO2 + H+ CO2 + H+ catechol + NADH The two substrates of this enzyme are (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are catechol, carbon dioxide, reduced NADH, and a proton.1.3.1.25 Reiner AM 1972 Metabolism of aromatic compounds in bacteria. Purification and properties of the catechol-forming enzyme, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD + ) oxidoreductase (decarboxylating) J. Biol. Chem. 247 4960–5 4341530 16 10.1016/S0021-9258(19)44924-7 free Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S 1992 cis-diol dehydrogenases encoded by the TOL pWW0 plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal benD gene are members of the short-chain alcohol dehydrogenase superfamily Eur. J. Biochem. 204 113–20 1740120 10.1111/j.1432-1033.1992.tb16612.x 1 free This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating). Other names in common use include 3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase, dihydrodihydroxybenzoate dehydrogenase, DHBDH, cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase, 2-hydro-1,2-dihydroxybenzoate dehydrogenase, cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+, oxidoreductase, and dihydrodihydroxybenzoate dehydrogenase. This enzyme participates in benzoate degradation via hydroxylation and benzoate degradation via coa ligation. References Biology no Category:EC 1.3.1 Category:NADH-dependent enzymes Category:Enzymes of unknown structure