10,11-Seco-LSD

vanc 6 10,11-Seco-LSD structure.svg skin-invert-image 150px Partial ergoline None 2640392-96-5 UCD0121; "[0124]"; 9,10-Didehydro-N,N-diethyl-6-methyl-10,11-secoergoline-8β-carboxamide O=C([C@@]1C=C[C@@]([H])(CC2=CN([H])C3=CC=CC=C23)N(C)C1)N(CC)CC 1S/C20H26N3O/c1-4-23(5-2)20(24)15-10-11-17(22(3)14-15)12-16-13-21-19-9-7-6-8-18(16)19/h6-11,13,17,21H,4-5,12,14H2,1-3H3/t17-/m0/s1 CGFPZODXTFFRAH-KRWDZBQOSA-N 10,11-Seco-LSD, also known as UCD0121, is a partial lysergamide and cyclized tryptamine related to lysergic acid diethylamide (LSD). Basargin AG, Domokosa A, Hennessey JJ, Aarrestad IK, Sambyal R, Khatib YA, Krüger J, Dunlap LE, Carter SJ, Rebek IA, McKee JL, Schalk SS, Liu M, Fettinger JC, Gonzalez MA, Potluri A, Tantillo DJ, Fiehn O, McCorvy JD, Olson DE Deconstruction of lysergic acid diethylamide Proc Natl Acad Sci U S A 123 38 e2603412123 September 2026 42709856 10.1073/pnas.2603412123 free Ergoline-like compounds for promoting neural plasticity 2021076572 WO Olson DE, Dunlap LM, Wagner F, Chytil M, Powell NE 22 April 2021 14 October 2020 14 October 2020 Delix Therapeutics, Inc. The Regents of the University of California https://patents.google.com/patent/WO2021076572/ [0124] In some embodiments, provided herein is a compound, or a pharmaceutically acceptable salt thereof, that is: [...] It is the seco analogue of LSD in which the bond between the 10 and 11 positions of the ergoline ring system has been broken. 10,11-Seco-LSD was described in a patent by David E. Olson and colleagues at Delix Therapeutics in 2021. Subsequently, 10,11-seco-LSD was further described by Olson and colleagues in the scientific literature in 2026. thumb|left|350px|class=skin-invert-image|LSD (left) and 10,11-seco-LSD (right) chemical structures. See also Partial lysergamide Seco-LSD Secoergoline NDTDI (8,10-seco-LSD) UCD0179 (3,5-seco-LSD) Mefloquine References Category:10,11-Secoergolines Category:Carboxamides Category:Diethylamides Category:N,N-Dialkyltryptamines Category:Partial ergolines Category:Tetrahydropyridines