16-Hydroxytabersonine

16-Hydroxytabersonine.svg 200px Methyl 16-hydroxy-2,3,6,7-tetradehydro-5α,12β,19α-aspidospermidine-3-carboxylate Methyl (3aR,3a1S,10bR)-3a-ethyl-8-hydroxy-3a,3a1,4,6,11,12-hexahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate 11-Hydroxytabersonine 22149-28-6 correct CAS 17699 2011510 C11643 correct FDA GV2G76UPD2 443326 391562 CC[C@]12CC(=C3[C@@]4([C@H]1N(CC4)CC=C2)c5ccc(cc5N3)O)C(=O)OC 1/C21H24N2O3/c1-3-20-7-4-9-23-10-8-21(19(20)23)15-6-5-13(24)11-16(15)22-17(21)14(12-20)18(25)26-2/h4-7,11,19,22,24H,3,8-10,12H2,1-2H3/t19-,20-,21-/m0/s1 FXUFRJQCBVSCRZ-ACRUOGEOBW 1S/C21H24N2O3/c1-3-20-7-4-9-23-10-8-21(19(20)23)15-6-5-13(24)11-16(15)22-17(21)14(12-20)18(25)26-2/h4-7,11,19,22,24H,3,8-10,12H2,1-2H3/t19-,20-,21-/m0/s1 FXUFRJQCBVSCRZ-ACRUOGEOSA-N 21 24 2 3 16-Hydroxytabersonine is a terpene indole alkaloid produced by the plant Catharanthus roseus. The metabolite is an intermediate in the formation of vindoline, a precursor needed for formation of the pharmaceutically valuable vinblastine and vincristine. 16-hydroxytabersonine is formed from the hydroxylation of tabersonine by tabersonine 16-hydroxylase (T16H). Tabersonine 16-O-methyltransferase (16OMT) methylates the hydroxylated 16 position to form 16-methoxytabersonine.Levac Dylan Murata Jun Kim Won S. De Luca Vincenzo 2008 Application of carborundum abrasion for investigating the leaf epidermis: Molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase The Plant Journal 53 2 225–236 10.1111/j.1365-313X.2007.03337.x 18053006 References Category:Indole alkaloids Category:Indolizinoindoles