2-Hydroxyisocaproic acid

Leucic acid.svg 200px 2-Hydroxy-4-methylpentanoic acid 2-Hydroxy-4-methylvaleric acid 498-36-2 correct CAS correct FDA 8RN4NSX3TY 92779 83753 CC(C)CC(C(=O)O)O 1/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9) LVRFTAZAXQPQHI-UHFFFAOYAQ 1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9) LVRFTAZAXQPQHI-UHFFFAOYSA-N 6 12 3 2-Hydroxyisocaproic acid (HICA or leucic acid) is a metabolite of the branched-chain amino acid leucine.24495238 Investigation of the presence of β-hydroxy-β-methylbutyric acid and α-hydroxyisocaproic acid in bovine whole milk and fermented dairy products by a validated liquid chromatography-mass spectrometry method. Journal of Agricultural and Food Chemistry 10.1021/jf500026s 62 7 February 2014 1506–11 Ehling Stefan Reddy Todime M. 2014JAFC...62.1506E It is commonly sold as a purported muscle building supplement.24125484 2-hydroxyisocaproic acid is fungicidal for Candida and Aspergillus species. Mycoses 10.1111/myc.12145 57 4 April 2014 214–21 Sakko M. Moore C. Novak-Frazer L. Rautemaa V. Sorsa T. Hietala P. Järvinen A. Bowyer P. Tjäderhane L. Rautemaa R. free 24106682 It also has fungicidal properties. HICA was shown to increase protein synthesis and muscle mass in rats who were recovering from a period of induced atrophy.23757407 Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy. American Journal of Physiology 10.1152/ajpendo.00618.2012 305 3 August 2013 E416–28 Lang Charles H. Pruznak Anne Navaratnarajah Maithili Rankine Kristina A. Deiter Gina Magne Hugues Offord Elizabeth A. Breuillé Denis HICA is also produced by several protozoans it has been reported to show anti- inflammatory activities.Westrop Gareth D. Wang Lijie Blackburn Gavin J. Zhang Tong Zheng Liang Watson David G. Coombs Graham H. 2017-12-21 Metabolomic profiling and stable isotope labelling of Trichomonas vaginalis and Tritrichomonas foetus reveal major differences in amino acid metabolism including the production of 2-hydroxyisocaproic acid, cystathionine and S-methylcysteine PLOS ONE 12 12 e0189072 10.1371/journal.pone.0189072 1932-6203 5739422 29267346 2017PLoSO..1289072W free References Category:Alpha hydroxycarboxylic acids Category:Fungicides