(RNA-polymerase)-subunit kinase

Class of enzymesJuly 2025 RNA polymerase subunit kinase 2.7.11.23 122097-00-1 0008353 In enzymology, an [RNA-polymerase]-subunit kinase (2.7.11.23) is an enzyme that catalyzes the chemical reaction ATP + [DNA-directed RNA polymerase] ADP + phospho-[DNA-directed RNA polymerase] Thus, the two substrates of this enzyme are ATP and DNA-directed RNA polymerase, whereas its two products are ADP and phospho-DNA-directed RNA polymerase. This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[DNA-directed RNA polymerase] phosphotransferase. Other names in common use include CTD kinase, and STK9. References Lee JM, Greenleaf AL 1989 A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II Proc. Natl. Acad. Sci. U.S.A. 86 3624–8 2657724 10.1073/pnas.86.10.3624 10 287190 1989PNAS...86.3624L free Biology no Category:EC 2.7.11 Category:Enzymes of unknown structure