2,2-Dimethoxypropane

changed changed 2,2-Dimethoxypropane at Sigma-Aldrich 477190426 2,2-Dimethoxypropane 2,2-Dimethoxypropane Structural Formula V1.svg 150px 2,2-dimethoxypropane-3D-balls.png 120px 2,2-dimethoxypropane ball view 2,2-Dimethoxypropane acetone dimethyl acetal CC(C)(OC)OC correct chemspider 21106033 6495 correct CAS 77-76-9 201-056-0 66P41R0030 3184215 1S/C5H12O2/c1-5(2,6-3)7-4/h1-4H3 HEWZVZIVELJPQZ-UHFFFAOYSA-N C5H12O2 104.15 g/mol Colorless liquid 0.85 g/cm3 15 g/L (20 °C) -47 83 External MSDS 02 07 Danger 225 315 319 335 210 233 240 241 242 243 261 264 271 280 302+352 303+361+353 304+340 305+351+338 312 321 332+313 337+313 362 370+378 403+233 403+235 405 501 2,2-Dimethoxypropane (DMP) is an organic compound with the formula (CH3)2C(OCH3)2. A colorless liquid, it is the product of the condensation of acetone and methanol. DMP is used as a water scavenger in water-sensitive reactions. Upon acid-catalyzed reaction, DMP reacts quantitatively with water to form acetone and methanol. This property can be used to accurately determine the amount of water in a sample, alternatively to the Karl Fischer method.Water determination by reaction with 2, 2-dimethoxypropane Critchfield, F. E. Bishop, E. T. Anal. Chem. 1961 33 8 1034 10.1021/ac60176a051Gas chromatographic method of moisture determination Martin, J. H. Knevel, A. M. J. Pharm. Sci. 1965 54 10 1464–7 10.1002/jps.2600541013 5883217 DMP is used to prepare acetonides from diols, where it is both a synthon for acetone and a scavenger for the water byproduct:D-(R)-Glyceraldehyde Acetonide Christopher R. Schmid Jerry D. Bryant Org. Synth. 1995 72 6 10.15227/orgsyn.072.0006 freeL-(S)-glyceraldehyde Acetonide Christian Hubschwerlen Jean-luc Specklin J. Higelin Org. Synth. 1995 72 1 10.15227/orgsyn.072.0001 free RCHOHCHOHCH2 + (CH3O)2C(CH3)2 → RCHCHCH2O2C(CH3)2 + 2 CH3OH It can also be used to prepare methyl esters from carboxylic acids, where it acts as a water scavenger and source of methanol: Lorette N. Brown, Jr. J. Notes- Use of Acetone Dimethyl Acetal in Preparation of Methyl Esters The Journal of Organic Chemistry 1959 24 2 261–262 10.1021/jo01084a633 RCOOH + CH3OH -> RCOOCH3 + H2O H2O + (CH3)2C(OCH3)2 —> 2CH3OH + (CH3)2C(O) Dimethoxypropane is an intermediate for the synthesis of 2-methoxypropene. In histology, DMP is used for the dehydration of animal tissue.Rapid dehydration--clearing with 2,2-dimethoxypropane for paraffin embedding Poul Prentø J. Histochem. Cytochem. 1978 26 10 865–867 10.1177/26.10.363931 363931 free References External links MSDS MSDS Category:Methylating agents Category:Ethers Category:Ketals Category:Reagents for organic chemistry