2,2'-Difluorofentanyl

Opioid analgesic designer drug vanc 6 2,2'-Difluorofentanyl Structure.svg skin-invert-image Schedule I Schedules of Controlled Substances:Temporary Placement of Fentanyl-Related Substances in Schedule I. Temporary amendment; temporary scheduling order Federal Register 83 25 5188–5192 February 2018 29932611 ((Drug Enforecement Administration)), ((Department of Justice)) 2748343-87-3 137700285 129434280 correct FDA B61QTX2SWO N-(2-Fluorophenyl)-N-[1-[2-(2-fluorophenyl)ethyl]piperidin-4-yl]propanamide 22 26 2 2 1 CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2F)C3=CC=CC=C3F 1S/C22H26F2N2O/c1-2-22(27)26(21 – 10-6-5-9-20(21)24)18 – 12 – 15-25(16 – 13 – 18)14 – 11 – 17-7-3-4-8 – 19(17)23/h3 – 10,18H,2,11 – 16H2,1H3 AUXYZYMWQUXVDV-UHFFFAOYSA-N 2,2'-Difluorofentanyl (2'-fluoro ortho-fluorofentanyl) is an opioid analgesic that is an analog of fentanyl which has been sold as a designer drug. Liu C, Li T, Han Y, Hua Z, Jia W, Qian Z The identification and analytical characterization of 2,2'-difluorofentanyl Drug Testing and Analysis 10 4 774–780 April 2018 28851108 10.1002/dta.2264 Walker E, Eneanya C, Mason TW, Akinfiresoye LR Effects of novel fentanyl derivatives in rats trained to discriminate morphine Neuropharmacology 276 September 2025 40374159 10.1016/j.neuropharm.2025.110509 110509 Side effects Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. Mounteney J, Giraudon I, Denissov G, Griffiths P Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe The International Journal on Drug Policy 26 7 626–631 July 2015 25976511 10.1016/j.drugpo.2015.04.003 A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week. Armenian P, Vo KT, Barr-Walker J, Lynch KL Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review Neuropharmacology 134 Pt A 121–132 May 2018 29042317 10.1016/j.neuropharm.2017.10.016 21404877 Legal status As a ring-substituted derivative of fentanyl, 2,2'-difluorofentanyl is banned under drug analog laws in the United States and other jurisdictions around the world.May 2019 See also Orthofluorofentanyl List of fentanyl analogues References Category:Anilides Category:Designer drugs Category:Mu-opioid receptor agonists Category:Piperidines Category:Synthetic opioids Category:2-Fluorophenyl compounds