2-hydroxy-6-oxonona-2,4-dienedioate hydrolase

Class of enzymes 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase (3.7.1.14, mhpC (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase. Burlingame R, Chapman PJ Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli Journal of Bacteriology 155 1 113–21 July 1983 10.1128/jb.155.1.113-121.1983 6345502 217659 Burlingame RP, Wyman L, Chapman PJ Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation Journal of Bacteriology 168 1 55–64 October 1986 10.1128/jb.168.1.55-64.1986 3531186 213419 Chemistry of extradiol aromatic ring cleavage: isolation of a stable dienol ring fission intermediate and stereochemistry of its enzymatic hydrolytic cleavage Lam WW, Bugg TD J. Chem. Soc., Chem. Commun. 1994 10 1163–1164 10.1039/c39940001163 10 Lam WW, Bugg TD Purification, characterization, and stereochemical analysis of a C-C hydrolase: 2-hydroxy-6-keto-nona-2,4-diene-1,9-dioic acid 5,6-hydrolase Biochemistry 36 40 12242–51 October 1997 9315862 10.1021/bi971115r Ferrández A, Garciá JL, Díaz E Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12 Journal of Bacteriology 179 8 2573–81 April 1997 10.1128/jb.179.8.2573-2581.1997 9098055 179006 Díaz E, Ferrández A, García JL Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12 Journal of Bacteriology 180 11 2915–23 June 1998 10.1128/JB.180.11.2915-2923.1998 9603882 107259 This enzyme catalyses the following chemical reaction: (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + succinate (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H2O (2Z)-2-hydroxypenta-2,4-dienoate + fumarate This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation. References External links 2-hydroxy-6-oxonona-2,4-dienedioate+hydrolase Biology no Category:EC 3.7.1