2'-hydroxybiphenyl-2-sulfinate desulfinase

Class of enzymes 2-(2-hydroxyphenyl)benzenesulfinate hydrolase 3.13.1.3 0018740 In enzymology, a 2'-hydroxybiphenyl-2-sulfinate desulfinase (3.13.1.3) is an enzyme that catalyzes the chemical reaction 2'-hydroxybiphenyl-2-sulfinate + H2O 2-hydroxybiphenyl + sulfite Thus, the two substrates of this enzyme are 2'-hydroxybiphenyl-2-sulfinate and H2O, whereas its two products are 2-hydroxybiphenyl and sulfite. This enzyme belongs to the family of hydrolases, specifically those acting on carbon-sulfur bonds. The systematic name of this enzyme class is 2'-hydroxybiphenyl-2-sulfinate sulfohydrolase. Other names in common use include gene dszB-encoded hydrolase, 2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase, DszB, HBPSi desulfinase, 2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase, HPBS desulfinase, 2-(2-hydroxyphenyl)benzenesulfinate hydrolase, 2-(2'-hydroxyphenyl)benzenesulfinate desulfinase, and 2-(2-hydroxyphenyl)benzenesulfinate desulfinase. Structural studies As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2DE2, 2DE3, and 2DE4. References 1 Oldfield C, Pogrebinsky O, Simmonds J, Olson ES, Kulpa CF Elucidation of the metabolic pathway for dibenzothiophene desulphurization by Rhodococcus sp. strain IGTS8 (ATCC 53968) Microbiology 143 9 2961–73 September 1997 9308179 10.1099/00221287-143-9-2961 free Nakayama N, Matsubara T, Ohshiro T, Moroto Y, Kawata Y, Koizumi K, Hirakawa Y, Suzuki M, Maruhashi K, Izumi Y, Kurane R A novel enzyme, 2'-hydroxybiphenyl-2-sulfinate desulfinase (DszB), from a dibenzothiophene-desulfurizing bacterium Rhodococcus erythropolis KA2-5-1: gene overexpression and enzyme characterization Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1598 1–2 122–30 July 2002 12147352 10.1016/s0167-4838(02)00365-5 Watkins LM, Rodriguez R, Schneider D, Broderick R, Cruz M, Chambers R, Ruckman E, Cody M, Mrachko GT Purification and characterization of the aromatic desulfinase, 2-(2'-hydroxyphenyl)benzenesulfinate desulfinase Archives of Biochemistry and Biophysics 415 1 14–23 July 2003 12801508 10.1016/S0003-9861(03)00230-3 Biology no Category:EC 3.13.1 Category:Enzymes of known structure