1,8-Cineole 2-endo-monooxygenase

Class of enzymes 1,8-Cineole 2-endo-monooxygenase 1.14.14.133 1,8-Cineole 2-endo-monooxygenase (1.14.14.133, Formerly 1.14.13.156, P450cin, CYP176A, CYP176A1) is an enzyme with systematic name 1,8-cineole,NADPH:oxygen oxidoreductase (2-endo-hydroxylating). Hawkes DB, Adams GW, Burlingame AL, Ortiz de Montellano PR, De Voss JJ Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization The Journal of Biological Chemistry 277 31 27725–32 August 2002 12016226 10.1074/jbc.M203382200 free Meharenna YT, Li H, Hawkes DB, Pearson AG, De Voss J, Poulos TL Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam Biochemistry 43 29 9487–94 July 2004 15260491 10.1021/bi049293p Kimmich N, Das A, Sevrioukova I, Meharenna Y, Sligar SG, Poulos TL Electron transfer between cytochrome P450cin and its FMN-containing redox partner, cindoxin The Journal of Biological Chemistry 282 37 27006–11 September 2007 17606612 10.1074/jbc.M703790200 free Meharenna YT, Slessor KE, Cavaignac SM, Poulos TL, De Voss JJ The critical role of substrate-protein hydrogen bonding in the control of regioselective hydroxylation in p450cin The Journal of Biological Chemistry 283 16 10804–12 April 2008 18270198 2447660 10.1074/jbc.M709722200 free This enzyme catalyses the following chemical reaction 1,8-cineole + NADPH + H+ + O2 2-endo-hydroxy-1,8-cineole + NADP+ + H2O 1,8-Cineole 2-endo-monooxygenase is a heme-thiolate protein (P-450). References External links 1,8-cineole+2-endo-monooxygenase Biology no Category:EC 1.14.14