2-hydroxyisoflavanone dehydratase

Class of enzymes 2-hydroxyisoflavanone dehydratase 4.2.1.105 56022-25-4 The enzyme 2-hydroxyisoflavanone dehydratase (4.2.1.105) catalyzes the chemical reaction 50% Q27123131 2,4',7-trihydroxyisoflavanone H2O daidzein This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,7,4′-trihydroxyisoflavanone hydro-lyase (daidzein-forming). This enzyme is also called 2,7,4′-trihydroxyisoflavanone hydro-lyase.4.2.1.105 This enzyme forms part of the pathway to isoflavones from flavonoids.Hakamatsuka T, Mori K, Ishida S, Ebizuka Y, Sankawa U 1998 Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata Phytochemistry 49 497–505 10.1016/S0031-9422(98)00266-0 2 Ververidis Filippos Trantas Emmanouil Douglas Carl Vollmer Guenter Kretzschmar Georg Panopoulos Nickolas October 2007 Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health Biotechnology Journal 2 10 1214–34 10.1002/biot.200700084 17935117 F The starting material, 2,4',7-trihydroxyisoflavanone, is produced from liquiritigenin by the enzyme isoflavonoid synthase Sawada Y, Kinoshita K, Akashi T, Aoki T, Ayabe S Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase The Plant Journal 31 5 555–64 September 2002 12207646 10.1046/j.1365-313x.2002.01378.x free 50% liquiritigenin Synthase Q27123131 2,4',7-trihydroxyisoflavanone 2-hydroxyisoflavanone dehydratase also acts on the intermediate tetrahydroxyisoflavanone produced from naringenin, leading to genistein.Bauters Lander Lander Bauers Stojilković Boris Gheysen Godelieve Pathogens pulling the strings: Effectors manipulating salicylic acid and phenylpropanoid biosynthesis in plants Molecular Plant Pathology British Society for Plant Pathology (Wiley) 2021-08-19 22 11 1464-6722 10.1111/mpp.13123 1436–1448 34414650 8518561 2021MolPP..22.1436B free 80% naringenin Synthase 2,4',5,7-tetrahydroxyisoflavanone H2O Dehydratase genistein The variant GmHID1 from Glycine max shows both these activities. References 1 Category:EC 4.2.1 Category:Enzymes of unknown structure Category:Isoflavonoids metabolism