2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase

Class of enzymes 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase 1.1.1.302 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase (1.1.1.302, 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase, MjaRED, MJ0671 (gene)) is an enzyme with systematic name 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase. Graupner M, Xu H, White RH The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin Journal of Bacteriology 184 7 1952–7 April 2002 11889103 134922 10.1128/JB.184.7.1952-1957.2002 Chatwell L, Krojer T, Fidler A, Römisch W, Eisenreich W, Bacher A, Huber R, Fischer M Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii Journal of Molecular Biology 359 5 1334–51 June 2006 16730025 10.1016/j.jmb.2006.04.045 This enzyme catalyses the following chemical reaction 65% Q27104794 2,5-diamino-6-(5-phosphono)ribitylamino-4(3H)-pyrimidinone + NAD+ reversible H+ H+ Q16869173 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + NADH The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH functions equally well as a reductant.1.1.1.302 References External links 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone+5'-phosphate+reductase Biology no Category:EC 1.1.1