2,6-dihydroxypyridine 3-monooxygenase

Class of enzymes 2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 39279-38-4 0018663 2,6-dihydroxypyridine 3-monooxygenase (1.14.13.10) is an enzyme that catalyzes the chemical reaction 60% 2,6-Dihydroxypyridine + NADH O2 + H+ H2O Q27102025 2,3,6-Trihydroxypyridine + NAD+ The four substrates of this enzyme are 2,6-dihydroxypyridine, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are 2,3,6-trihydroxypyridine, oxidised NAD+, and water.1.14.13.10Holmes PE, Rittenberg SC 1972 The bacterial oxidation of nicotine. VII. Partial purification and properties of 2,6-dihydroxypyridine oxidase J. Biol. Chem. 247 7622–7 4344227 23 10.1016/S0021-9258(19)44570-5 free Holmes PE, Rittenberg SC, Knackmuss HJ 1972 The bacterial oxidation of nicotine. 8. Synthesis of 2,3,6-trihydroxypyridine and accumulation and partial characterization of the product of 2,6-dihydroxypyridine oxidation J. Biol. Chem. 247 7628–33 4636328 23 10.1016/S0021-9258(19)44571-7 free The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is 2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating). This enzyme is also called 2,6-dihydroxypyridine oxidase. It uses flavin adenine dinucleotide as a cofactor.Montersino Stefania Tischler Dirk Gassner George T. Van Berkel Willem J. H. Catalytic and Structural Features of Flavoprotein Hydroxylases and Epoxidases Advanced Synthesis & Catalysis 2011 353 13 2301–2319 10.1002/adsc.201100384 References Biology no Category:EC 1.14.13 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Flavoproteins Category:Enzymes of unknown structure