12beta-hydroxysteroid dehydrogenase

Class of enzymes 12-beta-hydroxysteroid dehydrogenase 1.1.1.238 118390-62-8 0047521 In enzymology, a 12beta-hydroxysteroid dehydrogenase (1.1.1.238) is an enzyme that catalyzes the chemical reaction 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP+ 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+ Thus, the two substrates of this enzyme are 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate and NADP+, whereas its 3 products are 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 12beta-hydroxysteroid:NADP+ 12-oxidoreductase. Other names in common use include 12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), and dehydrogenase. References 1 Edenharder R, Pfutzner A 1988 Characterization of NADP-dependent 12 beta-hydroxysteroid dehydrogenase from Clostridium paraputrificum Biochim. Biophys. Acta 962 362–70 3167086 3 10.1016/0005-2760(88)90266-4 Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:Enzymes of unknown structure