2-oxoaldehyde dehydrogenase (NADP+)

Class of enzymes 2-oxoaldehyde dehydrogenase (NADP+) 1.2.1.49 83588-97-0 0047552 In enzymology, a 2-oxoaldehyde dehydrogenase (NADP+) (1.2.1.49) is an enzyme that catalyzes the chemical reaction a 2-oxoaldehyde + NADP+ + H2O a 2-oxo acid + NADPH + H+ The 3 substrates of this enzyme are 2-oxoaldehyde, NADP+, and H2O, whereas its 3 products are 2-oxo acid, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NADP+ 2-oxidoreductase. Other names in common use include alpha-ketoaldehyde dehydrogenase, methylglyoxal dehydrogenase, NADP+-linked alpha-ketoaldehyde dehydrogenase, 2-ketoaldehyde dehydrogenase, NADP+-dependent alpha-ketoaldehyde dehydrogenase, and 2-oxoaldehyde dehydrogenase (NADP+). This enzyme participates in pyruvate metabolism. References 1 Ray M, Ray S 1982 On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase J. Biol. Chem. 257 10571–4 7107626 18 10.1016/S0021-9258(18)33859-6 free Ray S, Ray M 1982 Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate J. Biol. Chem. 257 10566–70 7107625 18 10.1016/S0021-9258(18)33858-4 free Biology no Category:EC 1.2.1 Category:NADPH-dependent enzymes Category:Enzymes of unknown structure