1,2-Dichloropropane

1,3-dichloropropane changed changed 477203682 1,2-Dichloropropane at Sigma-Aldrich 1,2-dichloropropane skeletal.png skin-invert-image 150px 1,2-Dichloropropane Propylene dichloride, Propane, 1,2-dichloro- correct chemspider 6316 1/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3 KNKRKFALVUDBJE-UHFFFAOYAR correct EBI 44641 correct chemspider 1S/C3H6Cl2/c1-3(5)2-4/h3H,2H2,1H3 correct chemspider KNKRKFALVUDBJE-UHFFFAOYSA-N correct CAS 78-87-5 6564 82163 correct kegg C19034 correct FDA RRZ023OFWL 201-152-2 TX9625000 1279 ClCC(Cl)C 3 6 2 Colorless liquid like chloroform 1.156 g/cm3 −100 95 to 96 0.26 g/100 mL (at 20 °C) 40 mmHg (20°C) 16 557 07 08 Danger 225 302 332 350 201 202 210 233 240 241 242 243 261 264 270 271 280 281 301+312 303+361+353 304+312 304+340 308+313 312 330 370+378 403+235 405 501 2 3 0 TWA 75 ppm (350 mg/m3)0534 3.4%-14.5% Ca [400 ppm] Ca 2000 ppm (rat, 4 hr)720 ppm (mouse, 10 hr)2980 ppm (rat, 8 hr)78875 Propylene dichloride 860 mg/kg (mouse, oral)1947 mg/kg (rat, oral)2000 mg/kg (guinea pig, oral) 1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. It is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.Manfred Rossberg, Wilhelm Lendle, Gerhard Pfleiderer, Adolf Tögel, Eberhard-Ludwig Dreher, Ernst Langer, Heinz Rassaerts, Peter Kleinschmidt, Heinz Strack, Richard Cook, Uwe Beck, Karl-August Lipper, Theodore R. Torkelson, Eckhard Löser, Klaus K. Beutel, Trevor Mann "Chlorinated Hydrocarbons" in Ullmann's Encyclopedia of Industrial Chemistry 2006, Wiley-VCH, Weinheim. 10.1002/14356007.a06_233.pub2. Uses 1,2-Dichloropropane is an intermediate in the production of perchloroethylene, carbon tetrachloride and other chlorinated chemicals via chlorinolysis:Carl R. Noller, Chlorinated and Fluorinated Aliphatic Hydrocarbons in Chemistry of Organic Compounds (1957), page 722 {CH2-CHCl-CH2Cl} + 6 Cl2 -> {CCl4} + {CCl2=CCl2} + 6 HCl It was once used as a soil fumigant, chemical intermediate, as well as an industrial solvent and was found in paint strippers, varnishes, and furniture finish removers but some of these uses have been discontinued.https://wwwn.cdc.gov/TSP/ToxFAQs/ToxFAQsDetails.aspx?faqid=830&toxid=162 ToxFAQs for 1,2-Dichloropropane 2010-06-16 Carcinogenity Following several cases of bile duct cancer among Japanese printing firm employees, an investigation by the Japanese Ministry of Health, Labour and Welfare concluded in March 2013 that these cases were likely due to the use of cleaning agents containing 1,2-dichloropropane. Thus, there is reasonable evidence that 1,2-dichloropropane may be a carcinogen.Report by the Japanese Ministry of Health, Labour and WelfareArticle in the Yomiuri Shimbun Data from animal studies show tumor growth in the liver and mammary glands.CDC - NIOSH Pocket Guide to Chemical Hazards Further animal studies involving inhalation toxicity data has caused the National Institute for Occupational Safety and Health to classify 1,2-dichloropropane as a carcinogen and IDLH.Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs) References Category:Chloroalkanes Category:Sweet-smelling chemicals Category:IARC Group 1 carcinogens category:halogenated solvents