2-Methylmescaline

vanc 6 2-Methylmescaline structure.svg skin-invert-image 250px Serotonin receptor modulator None 154346781 2-Me-M; 2-Methyl-3,4,5-trimethoxyphenethylamine; 3,4,5-Trimethoxy-2-methylphenethylamine 2-(3,4,5-trimethoxy-2-methylphenyl)ethanamine 12 19 1 3 CC1=C(C(=C(C=C1CCN)OC)OC)OC 1S/C12H19NO3/c1-8-9(5-6-13)7-10(14-2)12(16-4)11(8)15-3/h7H,5-6,13H2,1-4H3 PCULFTFEHMIRBM-UHFFFAOYSA-N 2-Methylmescaline (2-Me-M), also known as 2-methyl-3,4,5-trimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and scaline families related to mescaline. Trachsel D, Lehmann D, Enzensperger C Phenethylamine: von der Struktur zur Funktion Solothurn 908–909 2013 Phenethylamines: From Structure to Function 1 Nachtschatten-Verlag Nachtschatten-Science 978-3-03788-700-4 858805226 https://books.google.com/books?id=-Us1kgEACAAJ de https://web.archive.org/web/20251113135159/https://books.google.com/books?id=-Us1kgEACAAJ 13 November 2025 26 November 2025 bot: unknown It is the 2-methyl derivative of mescaline. The drug shows affinity for the serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors (Ki = 525nM, 1,640nM, and 1,094nM, respectively). These affinities were 5.7-fold, 2.8-fold, and 7.1-fold higher than those of mescaline, respectively. The drug is not known to have been tested in animals or humans. 2-Methylmescaline was first described in the scientific literature by Daniel Trachsel and colleagues in 2013. The source of the information cited by Trachsel and colleagues was personal communication with David E. Nichols in 2010. It is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026 See also Scaline TeMPEA (2-methoxymescaline) 2-Bromomescaline 2-Chloromescaline 2-Iodomescaline Juno (6-methyl-DOM) DOTMA (Julia; 3,6-dimethyl-DOM) Ganesha (3-methyl-DOM) References External links 2-Methylmescaline - Isomer Design Category:Daniel Trachsel Category:David E. Nichols Category:Methyl compounds Category:Scalines Category:Serotonin receptor modulators