(S)-2-hydroxypropylphosphonic acid epoxidase

Class of enzymes (S)-2-hydroxypropylphosphonic acid epoxidase 1.11.1.23 (S)-2-hydroxypropylphosphonic acid epoxidase (1.11.1.23, HPP epoxidase, HppE, 2-hydroxypropylphosphonic acid epoxidase, Fom4, (S)-2-hydroxypropylphosphonate epoxidase) is an enzyme with systematic name (S)-2-hydroxypropylphosphonate,NADH:oxygen epoxidase. Yan F, Moon SJ, Liu P, Zhao Z, Lipscomb JD, Liu A, Liu HW Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues Biochemistry 46 44 12628–38 November 2007 17927218 2780580 10.1021/bi701370e Hidaka T, Goda M, Kuzuyama T, Takei N, Hidaka M, Seto H Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis Molecular & General Genetics 249 3 274–80 November 1995 7500951 10.1007/bf00290527 Liu P, Mehn MP, Yan F, Zhao Z, Que L, Liu HW Oxygenase activity in the self-hydroxylation of (s)-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin biosynthesis Journal of the American Chemical Society 126 33 10306–12 August 2004 15315444 10.1021/ja0475050 2004JAChS.12610306L Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme Nature 437 7060 838–44 October 2005 16015285 10.1038/nature03924 2005Natur.437..838H Cameron S, McLuskey K, Chamberlayne R, Hallyburton I, Hunter WN Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis Acta Crystallographica Section F 61 Pt 5 534–6 May 2005 16511089 1952317 10.1107/S1744309105012376 2005AcCrF..61..534C This enzyme catalyses the following chemical reaction 45% Q27104552 (S)-2-hydroxypropylphosphonic acid reversible H2O2 2 H2O 2 H2O H2O2 fosfomycin (S)-2-hydroxypropylphosphonic acid epoxidase contains one non-heme iron centre per monomer. The product is the antibiotic fosfomycin.1.11.1.23 Munos JW, Moon SJ, Mansoorabadi SO, Chang W, Hong L, Yan F, Liu A, Liu HW Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from Pseudomonas syringae Biochemistry 47 33 8726–35 August 2008 18656958 2780581 10.1021/bi800877v References External links (S)-2-hydroxypropylphosphonic+acid+epoxidase Biology no Category:EC 1.14.19