1-Iodomorphine

changed changed 477207909 1-Iodomorphine.svg 200px 1-Iodomorphine-3D-balls.png 220 1-Iodomorphine molecule 1-Iodo-17-methyl-7,8-didehydro-4,5α-epoxymorphinan-3,6α-diol (4R,4aR,7S,7aR,12bS)-11-Iodo-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol (5α,6α)-7,8-Didehydro-4,5-epoxy-1-iodo-17-methyl-morphinan-3,6-diol correct chemspider 9168496 1/C17H18INO3/c1-19-5-4-17-9-2-3-12(20)16(17)22-15-13(21)7-10(18)8(14(15)17)6-11(9)19/h2-3,7,9,11-12,16,20-21H,4-6H2,1H3/t9-,11+,12-,16-,17-/m0/s1 YFXOJQFZAJTGHD-GLWLLPOHBC correct chemspider 1S/C17H18INO3/c1-19-5-4-17-9-2-3-12(20)16(17)22-15-13(21)7-10(18)8(14(15)17)6-11(9)19/h2-3,7,9,11-12,16,20-21H,4-6H2,1H3/t9-,11+,12-,16-,17-/m0/s1 correct chemspider YFXOJQFZAJTGHD-GLWLLPOHSA-N changed ?? 64739-76-0 correct FDA 27HC478ARM 10993301 O[C@H]1\C=C/[C@H]4[C@H]2Cc5c3c(O[C@@H]1[C@]34CCN2C)c(O)cc5I 17 18 1 1 3 1-Iodomorphine is a semi-synthetic narcotic analgesic formed by halogenation of the 1 position on the morphine carbon skeleton. Liebman A. A. Malarek D. H. Blount J. F. Nelson N. R. Delaney C. M. Preparation and crystal structure of 6-acetyl-1-iodocodeine The Journal of Organic Chemistry 1978 43 4 737–739 10.1021/jo00398a049 Seltzman H. H. Roche M. J. Laudeman C. P. Wyrick C. D. Carroll F. I. Protection of the allylic alcohol double bond from catalytic reduction in the preparation of [1-3H]morphine and [1-3H]codeine Journal of Labelled Compounds and Radiopharmaceuticals 1998 41 9 811–821 10.1002/(SICI)1099-1344(1998090)41:9<811::AID-JLCR132>3.0.CO;2-3 Wentland M. P. Duan W. Cohen D. J. Bidlack J. M. Selective Protection and Functionalization of Morphine: Synthesis and Opioid Receptor Binding Properties of 3-Amino-3-desoxymorphine Derivatives Journal of Medicinal Chemistry 43 19 3558–3565 2000 10.1021/jm000119i 11000010 Halogenated morphine derivatives were first synthesised in Germany, Austria/Austria-Hungary, the United Kingdom and the United States in the period 1890 to 1930. Use of this drug increased after 1945 for the below-mentioned research. It is a research chemical which is often prepared in the laboratory when it is needed. Along with the similar 2-iodomorphine as well as iodinated analogs of dihydromorphine, dihydrocodeine, heroin, and the fluorinated, chlorinated, and brominated analogues of this series, this change may not impact the activity of the drug to a notable extentAugust 2010 but 1- and 2-iodomorphine are used in pharmacological, neurological, metabolic, and endocrine research as it allows the tagging of morphine with iodine-131 or iodine-129. Tafani J. A. Lazorthes Y. Danet B. Verdie J. C. Esquerre J. P. Simon J. Guiraud R. Human brain and spinal cord scan after intracerebroventricular administration of iodine-123 morphine International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology 1989 16 5 10.1016/0883-2897(89)90064-0 2807956 505–509 Such research was important in the discovery of opioid receptors in the central nervous system, peripheral nervous system, and other tissues in humans, mammals, birds, and some reptiles, amphibians, fish, insects, and arthropods. References 2 Category:Analgesics Category:4,5-Epoxymorphinans Category:Iodobenzene derivatives Category:Mu-opioid receptor agonists Category:Semisynthetic opioids