(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase

Class of enzymes (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase 2.4.1.92 67338-98-1 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase (2.4.1.92, uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase, ganglioside GM2 synthase, ganglioside GM3 acetylgalactosaminyltransferase, GM2 synthase, UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase, UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase, GM2/GD2-synthase, beta-1,4N-aetylgalactosaminyltransferase, asialo-GM2 synthase, GalNAc-T, UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:1-O-(O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase. Dicesare JL, Dain JA The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 231 2 385–93 March 1971 5554906 10.1016/0005-2760(71)90151-2 Pohlentz G, Klein D, Schwarzmann G, Schmitz D, Sandhoff K Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver Proceedings of the National Academy of Sciences of the United States of America 85 19 7044–8 October 1988 3140234 282120 10.1073/pnas.85.19.7044 1988PNAS...85.7044P free Hidari JK, Ichikawa S, Furukawa K, Yamasaki M, Hirabayashi Y beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F The Biochemical Journal 303 (Pt 3) 957–65 November 1994 3 7980468 1137639 10.1042/bj3030957 Hashimoto Y, Sekine M, Iwasaki K, Suzuki A Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver The Journal of Biological Chemistry 268 34 25857–64 December 1993 10.1016/S0021-9258(19)74467-6 8245020 free Nagai K, Ishizuka I Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain Journal of Biochemistry 101 5 1115–27 May 1987 3115968 10.1093/oxfordjournals.jbchem.a121976 free Furukawa K, Takamiya K, Furukawa K Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides Biochimica et Biophysica Acta (BBA) - General Subjects 1573 3 356–62 December 2002 12417418 10.1016/s0304-4165(02)00403-8 Yamashita T, Wu YP, Sandhoff R, Werth N, Mizukami H, Ellis JM, Dupree JL, Geyer R, Sandhoff K, Proia RL Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions Proceedings of the National Academy of Sciences of the United States of America 102 8 2725–30 February 2005 15710896 549464 10.1073/pnas.0407785102 2005PNAS..102.2725Y free This enzyme catalyses the following chemical reaction: UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively. References External links (N-acetylneuraminyl)-galactosylglucosylceramide+N-acetylgalactosaminyltransferase Biology no Category:EC 2.4.1