(S,S)-Tetrahydrochrysene

Chemical compound (S,S)-Tetrahydrochrysene (S,S)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol (S,S)-Tetrahydrochrysene.svg skin-invert-image 250 correct CAS 221368-54-3 correct FDA JDD6B8E8CW 10087373 8262910 312636 22 24 2 CC[C@H]1CC2=C(C=CC(=C2)O)C3=C1C4=C(C[C@@H]3CC)C=C(C=C4)O 1S/C22H24O2/c1-3-13-9-15-11-17(23)6-8-20(15)22-14(4-2)10-16-12-18(24)5-7-19(16)21(13)22/h5-8,11-14,23-24H,3-4,9-10H2,1-2H3/t13-,14-/m0/s1 MASYAWHPJCQLSW-KBPBESRZSA-N (S,S)-THC (S,S)-Tetrahydrochrysene ((S,S)-THC) is a steroid-like nonsteroidal estrogen and agonist of both the estrogen receptors, ERα and ERβ. Sun J, Meyers MJ, Fink BE, Rajendran R, Katzenellenbogen JA, Katzenellenbogen BS Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta Endocrinology 140 2 800–4 1999 9927308 10.1210/endo.140.2.6480 free It is an enantiomer of (R,R)-tetrahydrochrysene ((R,R)-THC), which, in contrast, is an ERβ silent antagonist and ERα agonist with 10-fold selectivity (i.e., affinity) for the ERβ over the ERα and with 20-fold greater affinity for the ERβ relative to that of (S,S)-THC. See also 2,8-DHHHC Chrysene References Category:Synthetic estrogens Category:Hydroxyarenes