2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

Class of enzymes 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase 3.5.1.66 95829-26-8 0047414 In enzymology, a 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase (3.5.1.66) is an enzyme that catalyzes the chemical reaction 2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH3 + CO2 Thus, the two substrates of this enzyme are 2-(hydroxymethyl)-3-(acetamidomethylene)succinate and H2O, whereas its 4 products are acetate, 2-(hydroxymethyl)-4-oxobutanoate, NH3, and CO2. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). Other names in common use include compound B hydrolase, alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid, and hydrolase. This enzyme participates in vitamin B6 metabolism. References 1 Huynh MS, Snell EE 1985 Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases J. Biol. Chem. 260 2379–83 3972793 4 10.1016/S0021-9258(18)89564-3 free Biology no Category:EC 3.5.1 Category:Enzymes of unknown structure