2'-N-acetylparomamine deacetylase

Class of enzymes 2'-N-acetylparomamine deacetylase 3.5.1.112 2'-N-acetylparomamine deacetylase (3.5.1.112, btrD (gene), neoL (gene), kanN (gene)) is an enzyme characterisd from Bacillus circulans with systematic name 2'-N-acetylparomamine hydrolase (acetate-forming).3.5.1.112 It catalyses the hydrolysi of 2'-N-acetylparomamine to paromamine and acetic acid: Truman AW, Huang F, Llewellyn NM, Spencer JB Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin Angewandte Chemie 46 9 1462–4 2007 17226887 10.1002/anie.200604194 2007ACIE...46.1462T 50% Q27133579 2'-N-acetylparomamine H2O CH3CO2H Q27107621 paromamine This enzyme takes part in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis ChemBioChem 9 6 865–9 April 2008 18311744 10.1002/cbic.200700717 Park Sung Ryeol Park Je Won Ban Yeon Hee Sohng Jae Kyung Yoon Yeo Joon 2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways Natural Product Reports 2013 30 1 11–20 10.1039/c2np20092a 23179168 Kudo Fumitaka Eguchi Tadashi Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs The Chemical Record 2016 16 1 4–18 10.1002/tcr.201500210 26455715 Guo Zhengyan Tang Yue Tang Wei Chen Yihua Heptose-containing bacterial natural products: Structures, bioactivities, and biosyntheses Natural Product Reports 2021 38 10 1887–1909 10.1039/d0np00075b 33704304 References External links 2'-N-acetylparomamine+deacetylase Biology no Category:EC 3.5.1