(R)-Ketoprofen

November 2025 vanc 6 R-Ketoprofen.svg skin-invert-image Oral Investigational 56105-81-8 180540 157105 S03709D0TH 372052 DB09214 (2R)-2-(3-benzoylphenyl)propanoic acid 16 14 3 C[C@H](C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m1/s1 DKYWVDODHFEZIM-LLVKDONJSA-N (R)-Ketoprofen (also called R(-)-ketoprofen) is the optically pure R-enantiomer of the NSAID ketoprofen. It functions as a cyclooxygenase inhibitor and has been investigated for potential use in conditions including tinnitus and neuropathic pain, although it is not approved for these indications. Methods for the treatment of tinnitus and other disorders using R(−)-ketoprofen https://patents.google.com/patent/US6362227B1/en Google Patents Sepracor, Inc. 2025-11-12 Background and development This method for treating tinnitus includes administration of substantially optically pure R(-)-ketoprofen. Methods for the treatment of tinnitus and other disorders using R(−)-ketoprofen (US6362227B1) https://patents.google.com/patent/US6362227B1/en Google Patents Sepracor, Inc. 2025-11-12 Mechanism of action As with other NSAIDs, R-ketoprofen inhibits the cyclooxygenase enzymes, thereby reducing the production of prostaglandins, which mediate inflammation, pain and potentially neurogenic processes. Its proposed application in tinnitus stems from the hypothesis that inflammatory or prostaglandin-mediated mechanisms might contribute to cochlear or auditory pathway dysfunction-associated tinnitus.Herbal Medicine Treatment for Children with Autism Spectrum Disorder: A Systematic Review Evidence-Based Complementary and Alternative Medicine 2017 8614680 10.1155/2017/8614680 free 28592982 5448044 Bang M, Lee SH, Cho S, Yu S, Kim K, Lu HY, Chang GT, Min SY Furthermore, the patent includes the statement that R-ketoprofen may be used in "methods of treating or preventing tinnitus or ringing in the ear" including conditions such as acoustic trauma, ototoxicity, cardiovascular diseases causing hearing loss. Methods for the treatment of tinnitus and other disorders using R(−)-ketoprofen (US6362227B1) https://patents.google.com/patent/US6362227B1/en Google Patents Sepracor, Inc. 2025-11-12 Investigational indications Tinnitus The patent application discloses R-ketoprofen for the treatment or prevention of tinnitus. Methods for the treatment of tinnitus and other disorders using R(−)-ketoprofen (US6362227B1) https://patents.google.com/patent/US6362227B1/en Google Patents Sepracor, Inc. 2025-11-12 Neuropathic pain The development overview also mentions "Phase-II for Neuropathic pain in USA (PO)" for R-ketoprofen. As of the last available update 2003, no further progression in trial reporting is publicly documented. R-ketoprofen – AdisInsight Drug Profile https://adisinsight.springer.com/drugs/800007136 AdisInsight / Springer Nature 2025-11-12 References 2 Category:Nonsteroidal anti-inflammatory drugs Category:Benzophenones Category:Carboxylic acids