2,3-Dimethylphenylpiperazine

2,3-Dimethylphenylpiperazine.svg skin-invert-image 200px Partial serotonin–norepinephrine releasing agent 1013-22-5 70541 63712 4J6RHZ6CSA 2335161 2,3-DMPP; 2,3-XP; PAL-218; PAL218 1-(2,3-dimethylphenyl)piperazine 12 18 2 CC1=C(C(=CC=C1)N2CCNCC2)C 1S/C12H18N2/c1-10-4-3-5-12(11(10)2)14-8-6-13-7-9-14/h3-5,13H,6-9H2,1-2H3 LIKXJDINUMWKQA-UHFFFAOYSA-N 2,3-Dimethylphenylpiperazine (2,3-DMPP; code name PAL-218) is a monoamine releasing agent and designer drug of the phenylpiperazine family. Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters J Pharmacol Exp Ther 341 1 251–262 April 2012 22271821 3364510 10.1124/jpet.111.188946 Severinsen K, Kraft JF, Koldsø H, Vinberg KA, Rothman RB, Partilla JS, Wiborg O, Blough B, Schiøtt B, Sinning S Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters ACS Chem Neurosci 3 9 693–705 September 2012 23019496 3447394 10.1021/cn300040f Takahashi M, Nagashima M, Suzuki J, Seto T, Yasuda I, Yoshida T Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry Talanta 77 4 1245–1272 February 2009 19084633 10.1016/j.talanta.2008.07.062 Analytical and Synthetic Studies on Designer Drugs of the Piperazine Class Office of Justice Programs 1 July 2014 https://www.ojp.gov/library/publications/analytical-and-synthetic-studies-designer-drugs-piperazine-class 13 March 2025 It acts as a partial serotonin–norepinephrine releasing agent (SNRA), with EC50 half-maximal effective concentration (Emax maximal efficacy) values of 24 to 26nM (85%) for serotonin, 13.7 to 56nM (62%) for norepinephrine, and 1,207 to 1,320nM (66%) for dopamine (22–96-fold lower than serotonin and norepinephrine). Its possible activities at serotonin receptors were not reported. The drug was first described in the scientific literature by 2009. See also para-Nitrophenylpiperazine (pNPP; PAL-175) 3-Trifluoromethyl-4-chlorophenylpiperazine (TFMCPP; PAL-179) References External links PAL-218 - Isomer Design Category:Designer drugs Category:Partial monoamine releasing agents Category:1-Phenylpiperazines Category:1-Piperazinyl compounds Category:Serotonin-norepinephrine releasing agents