2-oxoglutarate decarboxylase

Class of enzymes 2-oxoglutarate decarboxylase 4.1.1.71 37205-42-8 0008683 2xt9.jpg 270 2-oxoglutarate decarboxylase heterotetramer, Mycobacterium smegmatis The enzyme 2-oxoglutarate decarboxylase (4.1.1.71) catalyzes the chemical reaction: 2-oxoglutarate succinate semialdehyde + CO2 This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming). Other names in common use include oxoglutarate decarboxylase, alpha-ketoglutarate decarboxylase, alpha-ketoglutaric decarboxylase, oxoglutarate decarboxylase, pre-2-oxoglutarate decarboxylase, and 2-oxoglutarate carboxy-lyase. It employs one cofactor, thiamin diphosphate. References 1 Shigeoka S, Onishi T, Maeda K, Nakano Y, Kitaoka S 1986 Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis FEBS Lett. 195 1–2 43–47 10.1016/0014-5793(86)80126-0 1986FEBSL.195...43S Biology no Category:EC 4.1.1 Category:Thiamine enzymes Category:Enzymes of unknown structure