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2-Iodobenzoic acid
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changed 477213655 2-Iodobenzoic acid 2-Iodobenzoic acid.svg 120px 2-Iodobenzoic acid o-Iodobenzoic acid 88-67-5 correct CAS correct FDA 7Q00V80J7Q 6941 correct chemspider 6675 correct EBI 287979 O=C(O)c1ccccc1I correct EBI 112424 correct chemspider 1S/C7H5IO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10) correct chemspider CJNZAXGUTKBIHP-UHFFFAOYSA-N
C7H5IO2 248.018 g/mol white solid 2.25 g/cm3 162
4-Iodobenzoic acid
2-Iodobenzoic acid, or o-iodobenzoic acid, is an isomer of iodobenzoic acid.PubChem 2-Iodobenzoic acid https://pubchem.ncbi.nlm.nih.gov/compound/6941 2022-11-27 en The synthesis of 2-iodobenzoic acid via the diazotization of anthranilic acid is commonly performed in university organic chemistry labs. One of its most common uses is as a precursor for the preparation of IBX and Dess–Martin periodinane, both used as mild oxidants.
Synthesis
2-Iodobenzoic acid can be synthesized by a Sandmeyer reaction: the diazotization of anthranilic acid followed by a reaction with iodide.
500px|left|Diazo replacement of anthranilic acid.
Applications
Some of the known applications of 2-iodobenzoic acid include the following list of agents: mefenamic acid((Girisha, H. R.)), ((Srinivasa, G. R.)), ((Gowda, D. C.)) Journal of Chemical Research A simple and environmentally friendly method for the synthesis of N -phenylanthranilic acid derivatives 2006 5 342–344 May 2006 https://journals.sagepub.com/doi/10.3184/030823406777411098 10.3184/030823406777411098 28 August 2026 subscription flufenamic acid((Lednicer, D.)), ((Mitscher, L. A.)) 1977 The organic chemistry of drug synthesis. 1 Wiley 9780471521419((Wilkinson, J. H.)), ((Finar, I. L.)) Journal of the Chemical Society (Resumed) 6. A study of the properties of fluorine-substituted 5-aminoacridines and related compounds. Part II. 5-Amino-2-and -4-trifluoromethyl acridines 32 1948 https://pubs.rsc.org/jr/article/270485 0368-1769 10.1039/jr9480000032 28 August 2026 subscription Moxifetin, Ketoprofen, Chlorprothixene, Benodanil.((Nishiyama, Y.)), ((Nakamura, M.)), ((Misawa, T.)), ((Nakagomi, M.)), ((Makishima, M.)), ((Ishikawa, M.)), ((Hashimoto, Y.)) Bioorganic & Medicinal Chemistry Structure–activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand 22 9 2799–2808 May 2014 https://linkinghub.elsevier.com/retrieve/pii/S0968089614001801 09680896 10.1016/j.bmc.2014.03.007 28 August 2026
See also
4-Iodobenzoic acid
2-Chlorobenzoic acid
2-Fluorobenzoic acid
2-Bromobenzoic acid
References
Category:Benzoic acids
Category:2-Iodophenyl compounds