2-hydroxymuconate tautomerase

Class of enzymes 2-hydroxymuconate tautomerase 5.3.2.6 2-hydroxymuconate tautomerase (5.3.2.6, 4-oxalocrotonate tautomerase, 4-oxalocrotonate isomerase, cnbG (gene), praC (gene), xylH (gene)) is an enzyme with systematic name (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase. Chemical and enzymatic ketonization of 2-hydroxymuconate, a conjugated enol Whitman CP, Aird BA, Gillespie WR, Stolowich NJ J. Am. Chem. Soc. 1991 113 8 3154–3162 10.1021/ja00008a052 1991JAChS.113.3154W Stereospecific ketonization of 2-hydroxymuconate by 4-oxalocrotonate tautomerase and 5-(carboxymethyl)-2-hydroxymuconate isomerase Whitman CP, Hajipour G, Watson RJ, Johnson WH, Bembenek ME, Stolowich NJ J. Am. Chem. Soc. 1992 114 26 10104–10110 10.1021/ja00052a002 1992JAChS.11410104W Subramanya HS, Roper DI, Dauter Z, Dodson EJ, Davies GJ, Wilson KS, Wigley DB Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases Biochemistry 35 3 792–802 January 1996 8547259 10.1021/bi951732k Stivers JT, Abeygunawardana C, Mildvan AS, Hajipour G, Whitman CP, Chen LH Catalytic role of the amino-terminal proline in 4-oxalocrotonate tautomerase: affinity labeling and heteronuclear NMR studies Biochemistry 35 3 803–13 January 1996 8547260 10.1021/bi951077g Wang SC, Johnson WH, Czerwinski RM, Stamps SL, Whitman CP Kinetic and stereochemical analysis of YwhB, a 4-oxalocrotonate tautomerase homologue in Bacillus subtilis: mechanistic implications for the YwhB- and 4-oxalocrotonate tautomerase-catalyzed reactions Biochemistry 46 42 11919–29 October 2007 17902707 2531070 10.1021/bi701231a Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E Uncovering the protocatechuate 2,3-cleavage pathway genes Journal of Bacteriology 191 21 6758–68 November 2009 19717587 2795304 10.1128/JB.00840-09 This enzyme catalyses the following chemical reaction (2Z,4E)-2-hydroxyhexa-2,4-dienedioate (3E)-2-oxohex-3-enedioate Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols. References External links 2-hydroxymuconate+tautomerase. Biology no Category:EC 5.3.2