(acyl-carrier-protein) S-acetyltransferase

Class of enzymes [acyl-carrier-protein] S-acetyltransferase 2.3.1.38 37257-16-2 0004313 In enzymology, a [acyl-carrier-protein] S-acetyltransferase (2.3.1.38) is an enzyme that catalyzes the reversible chemical reaction acetyl-CoA + [acyl-carrier-protein] CoA + acetyl-[acyl-carrier-protein] Thus, the two substrates of this enzyme are acetyl-CoA and acyl carrier protein, whereas its two products are CoA and acetyl-acyl-carrier-protein. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase. Other names in common use include acetyl coenzyme A-acyl-carrier-protein transacylase, acetyl-CoA:ACP transacylase, [acyl-carrier-protein]acetyltransferase, [ACP]acetyltransferase, and ACAT. This enzyme participates in fatty acid biosynthesis. Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PFF. References 30em Prescott DJ, Vagelos PR Advances in Enzymology and Related Areas of Molecular Biology 1972 Acyl carrier protein 36 269–311 4561013 10.1002/9780470122815.ch8 Advances in Enzymology - and Related Areas of Molecular Biology 9780470122815 Vance DE, Mitsuhashi O, Bloch K 1973 Purification and properties of the fatty acid synthetase from Mycobacterium phlei J. Biol. Chem. 248 2303–9 4698221 7 10.1016/S0021-9258(19)44110-0 free Williamson IP, Wakil SJ 1966 Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases J. Biol. Chem. 241 2326–32 5330116 10 10.1016/S0021-9258(18)96625-1 free Lowe PN, Rhodes S 1988 Purification and characterization of acyl-carrier-protein acetyltransferase from Escherichia coli Biochem. J. 250 789–96 3291856 3 10.1042/bj2500789 1148925 Tsay JT, Oh W, Larson TJ, Jackowski S, Rock CO 1992 Isolation and characterization of the β-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12 J. Biol. Chem. 267 6807–14 1551888 10 10.1016/S0021-9258(19)50498-7 free Rangan VS, Smith S 1997 Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue J. Biol. Chem. 272 11975–8 9115261 10.1074/jbc.272.18.11975 18 free Biology no Category:EC 2.3.1 Category:Enzymes of known structure