12-hydroxydihydrochelirubine 12-O-methyltransferase

Class of enzymes 12-hydroxydihydrochelirubine 12-O-methyltransferase 2.1.1.120 158736-40-4 0030780 12-hydroxydihydrochelirubine 12-O-methyltransferase (2.1.1.120) is an enzyme that catalyzes the chemical reaction 65% Q74416981 12-hydroxydihydrochelirubine + SAM Q3707631 dihydromacarpine + SAH This is a methylation reaction in which the benzylisoquinoline alkaloid, 12-hydroxydihydrochelirubine, is converted to dihydromacarpine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Thalictrum bulgaricum.Kammerer L, De-Eknamkul W, Zenk MH 1994 Enzymic 12-hydroxylation and 12-O-methylation of dihydrochelirubine in dihydromacarpine formation by Thalictrum bulgaricum Phytochemistry 36 1409–1416 10.1016/S0031-9422(00)89732-0 6 1994PChem..36.1409K thumb|Macarpine This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase.2.1.1.120 The reaction is a late step in the biosynthesis of benzophenanthridine alkaloid, macarpine. References Biology no Category:EC 2.1.1 Category:Enzymes of unknown structure