2'''-acetyl-6'''-hydroxyneomycin C deacetylase

Class of enzymes 2'''-acetyl-6'''-hydroxyneomycin C deacetylase 3.5.1.113 2'''-acetyl-6'''-hydroxyneomycin C deacetylase (3.5.1.113, neoL (gene)) is an enzyme with systematic name 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming).3.5.1.113 It catalyses the hydrolysis of 2"'-acetyl-6"'-hydroxyneomycin C to 6"'-hydroxyneomycin C and acetic acid: Yokoyama K, Yamamoto Y, Kudo F, Eguchi T Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis ChemBioChem 9 6 865–9 April 2008 18311744 10.1002/cbic.200700717 70% Q27133603 2"'-acetyl-6"'-hydroxyneomycin C H2O CH3CO2H Q27133602 6"'-hydroxyneomycin C This enzyme is involved in biosynthesis of aminoglycoside antibiotics of the neomycin family.Kudo Fumitaka Eguchi Tadashi Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin Methods in Enzymology 2009 459 493–519 10.1016/S0076-6879(09)04620-5 19362652 978-0-12-374591-0 Clausnitzer D. Piepersberg W. Wehmeier U.F. The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin Journal of Applied Microbiology 2011 111 3 642–651 10.1111/j.1365-2672.2011.05082.x 21689223 References External links 2'''-acetyl-6'''-hydroxyneomycin C deacetylase Biology no Category:EC 3.5.1