2-chlorobenzoate 1,2-dioxygenase

Class of enzymes 2-chlorobenzoate 1,2-dioxygenase 1.14.12.13 125268-83-9 0018626 2-chlorobenzoate 1,2-dioxygenase (1.14.12.13) is an enzyme from the bacterium Burkholderia cepacia that catalyzes the chemical reaction 50% 2-Chlorobenzoic acid + NADH O2 CO2 Catechol + NAD+ + Cl- The four substrates of this enzyme are 2-chlorobenzoic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen and a proton. Its products are catechol, carbon dioxide, oxidised NAD+, and a chloride ion.1.14.12.13 10.1515/bchm3.1989.370.2.1173 Fetzner S, Muller R, Lingens F 1989 Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS Biol. Chem. Hoppe-Seyler 370 1173–82 2610934 11 This enzyme is an oxidoreductase that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of its class is 2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating). This enzyme is also called 2-halobenzoate 1,2-dioxygenase. It can oxidise other 2-halo substituted benzoic acids. References Biology no Category:EC 1.14.12 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Iron enzymes Category:Enzymes of unknown structure